SLC26A2 deficiency, matrix stiffness and mechanotransduction linked in osteoporosis Page 1
nature reviewsrheumatology https://doi.org/10.1038/s41584-023-01041-0 Research highlights …

SLC4A2 belongs to the Na+-independent solute carrier family 4 (SLC4) of anion
exchangers, which regulate electroneutral exchange of Cl− for HCO 3− and mediate intra …

Sulfation is a widespread modification of biomolecules that has been incompletely explored
to date. Through cross-phenotype meta-analysis of bone mineral density in up to 426,824 …

Sulfate plays a pivotal role in numerous physiological processes in the human body,
including bone and cartilage health. A role of the anion transporter SLC26A1 (Sat1) for …

Bone remodeling requires osteoclasts to generate and maintain an acidified resorption
compartment between the apical membrane and the bone surface to solubilize …

Osteopetrosis is a group of rare inherited skeletal disorders characterized by a marked
increase in bone density due to deficient bone resorption. Pathogenic variants in several …

As the only cell capable of bone resorption, the osteoclast is a central mediator of skeletal
homeostasis and disease. To efficiently degrade mineralized tissue, these multinucleated …

Back pain is a common and debilitating disorder with largely unknown underlying biology.
Here we report a genome-wide association study of back pain using diagnoses assigned in …

Using genomic applications to glean insights into human biology, we systematically
searched for nonsense single nucleotide variants (SNVs) that are rare in the general …

Confusion persists over pathogenesis of spondylolysis. To confirm pathogenicity of the
previously identified causative mutation of spondylolysis and investigate the genetic …