Imaging genetics of schizophrenia in the post-GWAS era
A Arslan - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
Imaging genetics is a research methodology studying the effect of genetic variation on brain
structure, function, behavior, and risk for psychopathology. Since the early 2000s, imaging …
structure, function, behavior, and risk for psychopathology. Since the early 2000s, imaging …
Mapping the schizophrenia genes by neuroimaging: the opportunities and the challenges
A Arslan - International Journal of Molecular Sciences, 2018 - mdpi.com
Schizophrenia (SZ) is a heritable brain disease originating from a complex interaction of
genetic and environmental factors. The genes underpinning the neurobiology of SZ are …
genetic and environmental factors. The genes underpinning the neurobiology of SZ are …
Imaging genetics towards a refined diagnosis of schizophrenia
Current diagnoses of schizophrenia and related psychiatric disorders are classified by
phenomenological principles and clinical descriptions while ruling out other symptoms and …
phenomenological principles and clinical descriptions while ruling out other symptoms and …
Structural and functional neuroimaging of polygenic risk for schizophrenia: a recall-by-genotype–based approach
TM Lancaster, SL Dimitriadis, KE Tansey… - Schizophrenia …, 2019 - academic.oup.com
Risk profile scores (RPS) derived from genome-wide association studies (GWAS) explain a
considerable amount of susceptibility for schizophrenia (SCZ). However, little is known …
considerable amount of susceptibility for schizophrenia (SCZ). However, little is known …
Imaging phenotypes and genotypes in schizophrenia
Schizophrenia is associated with subtle structural and functional brain abnormalities. Both
recent and classical data suggest that it is a heterogeneous disorder that is clearly heritable …
recent and classical data suggest that it is a heterogeneous disorder that is clearly heritable …
Genomic and imaging biomarkers in schizophrenia
JT Reddaway, JL Doherty, T Lancaster, D Linden… - Biomarkers in …, 2018 - Springer
Recent large-scale genomic studies have confirmed that schizophrenia is a polygenic
syndrome and have implicated a number of biological pathways in its aetiology. Both …
syndrome and have implicated a number of biological pathways in its aetiology. Both …
The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: a collaborative cognitive and neuroimaging genetics project
Background Schizophrenia has a large genetic component, and the pathways from genes to
illness manifestation are beginning to be identified. The Genetics of Endophenotypes of …
illness manifestation are beginning to be identified. The Genetics of Endophenotypes of …
Limited evidence for association of genome-wide schizophrenia risk variants on cortical neuroimaging phenotypes
Background: There are now over 100 established genetic risk variants for schizophrenia;
however, their influence on brain structure and circuitry across the human lifespan are not …
however, their influence on brain structure and circuitry across the human lifespan are not …
Population-based mapping of polygenic risk for schizophrenia on the human brain: New opportunities to capture the dimensional aspects of severe mental disorders
LT Westlye, D Alnæs… - Biological …, 2019 - biologicalpsychiatryjournal.com
Schizophrenia remains one of the major enigmas in modern biomedicine. The lack of
knowledge about disease mechanisms has hampered the development of preventive …
knowledge about disease mechanisms has hampered the development of preventive …
Brain vs behavior: an effect size comparison of neuroimaging and cognitive studies of genetic risk for schizophrenia
Genetic variants associated with increased risk for schizophrenia (SZ) are hypothesized to
be more penetrant at the level of brain structure and function than at the level of behavior …
be more penetrant at the level of brain structure and function than at the level of behavior …