Imaging genetics of schizophrenia in the post-GWAS era

A Arslan - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
Imaging genetics is a research methodology studying the effect of genetic variation on brain
structure, function, behavior, and risk for psychopathology. Since the early 2000s, imaging …

Mapping the schizophrenia genes by neuroimaging: the opportunities and the challenges

A Arslan - International Journal of Molecular Sciences, 2018 - mdpi.com
Schizophrenia (SZ) is a heritable brain disease originating from a complex interaction of
genetic and environmental factors. The genes underpinning the neurobiology of SZ are …

Imaging genetics towards a refined diagnosis of schizophrenia

W Jiang, TZ King, JA Turner - Frontiers in psychiatry, 2019 - frontiersin.org
Current diagnoses of schizophrenia and related psychiatric disorders are classified by
phenomenological principles and clinical descriptions while ruling out other symptoms and …

Structural and functional neuroimaging of polygenic risk for schizophrenia: a recall-by-genotype–based approach

TM Lancaster, SL Dimitriadis, KE Tansey… - Schizophrenia …, 2019 - academic.oup.com
Risk profile scores (RPS) derived from genome-wide association studies (GWAS) explain a
considerable amount of susceptibility for schizophrenia (SCZ). However, little is known …

Imaging phenotypes and genotypes in schizophrenia

JA Turner, P Smyth, F Macciardi, JH Fallon… - Neuroinformatics, 2006 - Springer
Schizophrenia is associated with subtle structural and functional brain abnormalities. Both
recent and classical data suggest that it is a heterogeneous disorder that is clearly heritable …

Genomic and imaging biomarkers in schizophrenia

JT Reddaway, JL Doherty, T Lancaster, D Linden… - Biomarkers in …, 2018 - Springer
Recent large-scale genomic studies have confirmed that schizophrenia is a polygenic
syndrome and have implicated a number of biological pathways in its aetiology. Both …

The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: a collaborative cognitive and neuroimaging genetics project

GAM Blokland, EC Del Re, RI Mesholam-Gately… - Schizophrenia …, 2018 - Elsevier
Background Schizophrenia has a large genetic component, and the pathways from genes to
illness manifestation are beginning to be identified. The Genetics of Endophenotypes of …

Limited evidence for association of genome-wide schizophrenia risk variants on cortical neuroimaging phenotypes

AN Voineskos, D Felsky, AL Wheeler… - Schizophrenia …, 2016 - academic.oup.com
Background: There are now over 100 established genetic risk variants for schizophrenia;
however, their influence on brain structure and circuitry across the human lifespan are not …

Population-based mapping of polygenic risk for schizophrenia on the human brain: New opportunities to capture the dimensional aspects of severe mental disorders

LT Westlye, D Alnæs… - Biological …, 2019 - biologicalpsychiatryjournal.com
Schizophrenia remains one of the major enigmas in modern biomedicine. The lack of
knowledge about disease mechanisms has hampered the development of preventive …

Brain vs behavior: an effect size comparison of neuroimaging and cognitive studies of genetic risk for schizophrenia

EJ Rose, G Donohoe - Schizophrenia bulletin, 2013 - academic.oup.com
Genetic variants associated with increased risk for schizophrenia (SZ) are hypothesized to
be more penetrant at the level of brain structure and function than at the level of behavior …