Background. Platinum-based anticancer drugs are widely used in the chemotherapy of
human neoplasms. The major obstacle for the clinical use of this class of drugs is the …

Cisplatin and its analogs have become important components of chemotherapeutic
regimens for the treatment of solid tumors, however, their overall effectiveness is limited by …

Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce
tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity …

The accidental discovery of the anticancer properties of cisplatin and its clinical introduction
in the 1970s represent a major landmark in the history of successful anticancer drugs …

Cisplatin is a chemotherapeutic drug that has been used in the treatment of various types of
human cancers such as ovarian, lung, head and neck, testicular and bladder. Cisplatin has …

The processes by which cells develop resistance to antitumor platinum drugs have been the
subject of intense research because resistance is a major obstacle for the clinical use of this …

Cisplatin (cis-diamminedichloroplatinum (II)) is the oldest known chemotherapeutic agent.
Since the identification of its anti-tumour activity, it earned a remarkable place as a treatment …

Biochemical modulation is the manipulation of cellular biochemical pathways by chemical
agents to produce selective enhancement of the efficacy of an antitumor drug. 1 Since the …

Cisplatin plays a central role in cancer chemotherapy in spite of its toxicity. To circumvent
this toxicity and to enhance its therapeutic index a lot of preclinical and clinical studies have …

Cisplatin and carboplatin are among the most active and widely used cytotoxic anticancer
drugs. However, the acquisition or presence of resistance significantly undermines the …