Objectives Fluoroquinolone (FQ) prophylaxis was recommended in 2005 by European
Conference on Infections in Leukemia (ECIL) for patients with prolonged neutropenia. In …

BACKGROUND: The routine use of fluoroquinolone prophylaxis in patients with neutropenia
and hematological malignancies is controversial. This prophylaxis has been reported to …

A recent meta-analysis, which included non-placebo open-labeled trials, showed that
fluoroquinolone prophylaxis reduces mortality in neutropenic patients, whereas two recent …

Background. Fluoroquinolone prophylaxis during neutropenia in patients with cancer has
been associated with decreased incidence of gram-negative bacteremia. Bacterial …

These recommendations have been developed by an expert panel following an evidence-
based search of the literature assessing the role of fluoroquinolones in the prevention of …

Purpose: Past reports and meta-analyses indicate that fluoroquinolones are highly effective
in preventing Gram-negative infections in neutropenic cancer patients, but offer inadequate …

We conducted a two-part meta-analysis to assess the effectiveness of fluoroquinolones for
preventing bacterial infections in granulocytopenic patients who are receiving chemotherapy …

New evidence shows that antibiotic prophylaxis in neutropenic patients reduces mortality,
febrile episodes, and bacterial infections. For patients with acute leukemia or those who …

The use of oral prophylactic antibiotics in patients with neutropenia is controversial and not
recommended by this group because of a lack of evidence showing a reduction in mortality …

The use of antibiotic prophylaxis in neutropenic patients remains controversial. The main
arguments against prophylaxis are the lack of survival benefit and the risk of inducing …