Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 is largely the result of
a dysregulated host response, followed by damage to alveolar cells and lung fibrosis …

Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we …

Nrf2 is a transcription factor that regulates cellular redox balance and the expression of a
wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 …

The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …

Several viruses have been shown to modulate the transcription factor nuclear factor
erythroid 2-related factor 2 (NRF2), the master regulator of redox homeostasis. The severe …

COVID-19 is a pandemic requiring immediate solution for treatment because of its complex
pathophysiology. Exploration of novel targets and thus treatment will be life savers which is …

Nrf2 is a key transcription factor responsible for antioxidant defense in many tissues and
cells, including alveolar epithelium, endothelium, and macrophages. Furthermore, Nrf2 …

Novel mechanistic insights are discussed herein that link a single, nontoxic, low-dose
radiotherapy (LDRT) treatment (0.5–1.0 Gy) to (1) beneficial subcellular effects mediated by …

Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently
leads to fatal inflammatory responses and acute lung injury. Here, we discuss the various …

Background Coronavirus-associated acute respiratory distress syndrome (CARDS) has
limited effective therapy to date. NLRP3 inflammasome activation induced by SARS-CoV-2 …