Simple Summary DNA damage is one of the hallmarks of cancer. Epithelial ovarian cancer
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …

Prostate cancer ranks fifth in cancer-related mortality in men worldwide. DNA damage is
implicated in cancer and DNA damage response (DDR) pathways are in place against this …

Germline and somatic aberrations in DNA damage repair (DDR) genes are more prevalent
in prostate cancer than previously recognized, with BRCA2 as the most commonly altered …

Ovarian cancer is the leading cause of death among gynecological cancers. It exhibits great
heterogeneity in tumor biology and treatment response. Germline mutations of DNA repair …

Background Germline mutations in the BRCA1 or BRCA2 (BRCA) genes predispose to
hereditary breast and ovarian cancer and, mostly in the case of BRCA2, are also prevalent …

High grade serous ovarian cancer (HGSOC) is the most common epithelial ovarian cancer,
harbouring more than 20% germline or somatic mutations in the tumour suppressor genes …

Despite chemotherapy and novel androgen‐receptor signalling inhibitors (ARSi) have been
approved during the last decades, metastatic castration‐resistant prostate cancer (mCRPC) …

Abstract The US Food and Drug Administration recently approved two poly‐adenosine
diphosphate‐ribose polymerase (PARP) inhibitors, olaparib and rucaparib, for treatment of …

Over the past years, several studies have demonstrated that defects in DNA damage
response and repair (DDR) genes are present in a significant proportion of patients with …

Therapeutic exploitation of the synthetic lethality between poly (ADP-ribose) polymerase
(PARP) and BRCA1/2 is highly promising [1]. Trials have focused on ovarian and breast …