Drug-induced organ toxicity/injury, especially in the liver, kidney, and gastrointestinal tract, is
a systematic disorder that causes oxidative stress formation and inflammation resulting in …

Connexin32 is the building block of hepatocellular gap junctions, which control direct
intercellular communication and thereby act as goalkeepers of liver homeostasis. This study …

Cadmium (Cd) is a significant environmental contaminant known for its potential hepatotoxic
effects. However, the precise mechanisms underlying Cd-induced hepatotoxicity have yet to …

Hepatic ischemia/reperfusion (I/R) injury is a common complication in the clinical setting.
Our previous study has shown that connexin 32 (Cx32) plays a major role in renal I/R injury; …

Objective: Liver fibrosis results from the perpetuation of the normal wound healing response
to several types of injury. Despite the wealth of knowledge regarding the involvement of …

Postoperative acute kidney injury (AKI) is a severe complication after liver transplantation
(LT). Its deterioration and magnification lead to the increase in mortality. Connexin43 (Cx43) …

Primary hepatocyte cultures suffer from the progressive occurrence of dedifferentiation
followed by spontaneous apoptosis. This is associated with modifications in the expression …

Drug-induced liver injury (DILI) limits the development and application of many therapeutic
compounds and presents major challenges to the pharmaceutical industry and clinical …

Whether metabolites derived from injured renal tubular epithelial cells (TECs) participate in
renal fibrosis is poorly explored. After TEC injury, various metabolites are released and …

Gap junction intercellular communication is involved in ischemia–reperfusion (IR) injury of
organs. Connexins are proteins that are critical to the function of gap junctions. To clarify the …