The vascular network delivers oxygen (O2) and nutrients to all cells within the body. It is
therefore not surprising that O2 availability serves as a primary regulator of this complex …

The mechanisms that regulate angiogenesis in hypoxia or hypoxic microenvironment are
modulated by several pro-and antiangiogenic factors. Hypoxia-inducible factors (HIFs) have …

Angiogenesis is mostly an adaptive response to tissue hypoxia, which occurs under a wide
variety of situations ranging from embryonic development to tumor growth. In general …

Maintenance of oxygen homeostasis is critical for the survival of multicellular organs. As a
result, both invertebrates and vertebrates have developed highly specialized mechanisms to …

Angiogenesis is a key enabling feature of mammalian embryonic development and tumor
progression, which provides oxygen and nutrients that are required for vessel growth and …

The regulation of angiogenesis by hypoxia is an important component of homeostatic
mechanisms that link vascular oxygen supply to metabolic demand. Molecular …

Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion
distances from the existing vascular supply increases resulting in hypoxia. Sustained …

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …

Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in
ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified …

Blood vessels function as conduits for the delivery of O2 and nutrients. Hypoxia-inducible
factor 1 (HIF-1) mediates adaptive transcriptional responses to hypoxia/ischemia that …