Sex-related differences in response to masseteric injections of glutamate and nerve growth factor in healthy human participants

AM Alhilou, A Shimada, CI Svensson, P Svensson… - Scientific reports, 2021 - nature.com
The neurophysiological mechanisms underlying NGF-induced masseter muscle
sensitization and sex-related differences in its effect are not well understood in humans …

Functional change in experimental allodynia after glutamate-induced pain in the human masseter muscle

A Shimada, AM Alhilou, P Svensson, M Ernberg… - Frontiers in oral …, 2020 - frontiersin.org
Background: Glutamate, as well as nerve growth factor (NGF), is involved in nociception
from peripheral tissues, such as muscles. However, the potential interaction between …

Nerve growth factor and glutamate increase the density and expression of substance P-containing nerve fibers in healthy human masseter muscles

AM Alhilou, A Shimada, CI Svensson, P Svensson… - Scientific Reports, 2021 - nature.com
Nocifensive behavior induced by injection of glutamate or nerve growth factor (NGF) into rats
masseter muscle is mediated, in part, through the activation of peripheral NMDA receptors …

NGF-induced mechanical sensitization of the masseter muscle is mediated through peripheral NMDA receptors

H Wong, I Kang, XD Dong, N Christidis, M Ernberg… - Neuroscience, 2014 - Elsevier
Intramuscular injection of nerve growth factor (NGF) in healthy humans mimics some of the
symptoms of myofascial temporomandibular disorders (M-TMD). We hypothesized that NGF …

Nerve growth factor alters the sensitivity of rat masseter muscle mechanoreceptors to NMDA receptor activation

H Wong, XD Dong, BE Cairns - Journal of Neurophysiology, 2014 - journals.physiology.org
Intramuscular injection of nerve growth factor (NGF) into rat masseter muscle induces a local
mechanical sensitization that is greater in female than in male rats. The duration of NGF …

Local anaesthesia decreases nerve growth factor induced masseter hyperalgesia

YM Costa, FG Exposto, EE Castrillon, PCR Conti… - Scientific Reports, 2020 - nature.com
The aim of this investigation was to evaluate the effects of local anaesthesia on nerve growth
factor (NGF) induced masseter hyperalgesia. Healthy participants randomly received an …

[PDF][PDF] Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women.

EE Castrillon, BE Cairns, M Ernberg, K Wang… - Journal of orofacial …, 2007 - files.jofph.com
Aims: To test the hypothesis that local injection of the N-methyl-D-aspartate (NMDA) receptor
antagonist ketamine would significantly attenuate glutamate-evoked masseter mechanical …

Human nerve growth factor sensitizes masseter muscle nociceptors in female rats

P Svensson, MW Wang, XD Dong, U Kumar, BE Cairns - PAIN®, 2010 - Elsevier
Injection of nerve growth factor (NGF) into the masseter muscle is not painful but does
induce a localized, quick onset (∼ 1h) and long-lasting mechanical sensitization in healthy …

Injection of nerve growth factor into human masseter muscle evokes long-lasting mechanical allodynia and hyperalgesia

P Svensson, BE Cairns, K Wang, L Arendt-Nielsen - Pain, 2003 - Elsevier
Nerve growth factor (NGF) is a neurotrophic protein with a pivotal role in development and
maintenance of the nervous system on one side and inflammatory and neuropathic pain …

Effects of NGF-induced muscle sensitization on proprioception and nociception

P Svensson, K Wang, L Arendt-Nielsen… - Experimental brain …, 2008 - Springer
Temporomandibular disorders (TMDs) are associated with perturbation of proprioceptive
and nociceptive function. Recent studies have shown that injection of the neurotrophic …