Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it
downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is …

The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress
synaptic transmission and plays a major role in a diverse range of brain functions including …

In central neurons, the cell-surface distribution of cannabinoid receptor subtype-1 (CB1) is
highly polarized toward axons and is associated with synaptic terminals, in which it is well …

Defining functional domains and amino acid residues in G protein coupled receptors
(GPCRs) represent an important way to improve rational drug design for this major class of …

Endocannabinoid signalling mediated by cannabinoid receptor 1 (CB1R, also known as
CNR1) is critical for homeostatic neuromodulation of both excitatory and inhibitory synapses …

The type 1 cannabinoid receptor (CB1R) is one of the most abundant G-protein-coupled
receptors (GPCRs) in the brain, predominantly localized to axons of GABAergic neurons …

Presynaptic cannabinoid type 1 receptors (CB1Rs) are major mediators of retrograde
synaptic plasticity at both excitatory and inhibitory synapses and participate in a plethora of …

The type 1 cannabinoid receptor (CB1 receptor) is considered to be the most abundant G
protein-coupled receptor (GPCR) in the mammalian brain. The presence and highly …

Chronic cannabinoid exposure results in tolerance due to region-specific desensitization
and down-regulation of CB1 cannabinoid receptors (CB1Rs). For most G-protein-coupled …

Endocannabinoids, acting via type 1 cannabinoid receptors (CB1), are known to be involved
in short-term synaptic plasticity via retrograde signaling. Strong depolarization of the …