[HTML][HTML] Integrin targeted therapeutics

M Millard, S Odde, N Neamati - Theranostics, 2011 - ncbi.nlm.nih.gov
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors,
adhesion molecules and signal transduction platforms in a multitude of biological processes …

[HTML][HTML] Targeting integrin pathways: mechanisms and advances in therapy

X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Integrin modulators: a patent review

TG Kapp, F Rechenmacher, TR Sobahi… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Integrins are heterodimeric cell surface receptors, which enable adhesion,
proliferation, and migration of cells by recognizing binding motifs in extracellular matrix …

Integrins as therapeutic targets

SL Goodman, M Picard - Trends in pharmacological sciences, 2012 - cell.com
Integrins are a large family of molecules that are central regulators in multicellular biology.
They orchestrate cell–cell and cell–extracellular matrix (ECM) adhesive interactions from …

Integrins as therapeutic targets: lessons and opportunities

D Cox, M Brennan, N Moran - Nature reviews Drug discovery, 2010 - nature.com
The integrins are a large family of cell adhesion molecules that are essential for the
regulation of cell growth and function. The identification of key roles for integrins in a diverse …

[HTML][HTML] Integrins as therapeutic targets: successes and cancers

S Raab-Westphal, JF Marshall, SL Goodman - Cancers, 2017 - mdpi.com
Integrins are transmembrane receptors that are central to the biology of many human
pathologies. Classically mediating cell-extracellular matrix and cell-cell interaction, and with …

Therapeutic antagonists and conformational regulation of integrin function

M Shimaoka, TA Springer - Nature Reviews Drug Discovery, 2003 - nature.com
Integrins are a structurally elaborate family of adhesion molecules that transmit signals bi-
directionally across the plasma membrane by undergoing large-scale structural …

[HTML][HTML] Why integrin as a primary target for imaging and therapy

G Niu, X Chen - Theranostics, 2011 - ncbi.nlm.nih.gov
Integrin-mediated cell adhesion is involved in many essential normal cellular and
pathological functions including cell survival, growth, differentiation, migration, inflammatory …

[HTML][HTML] Integrins in the spotlight of cancer

D Bianconi, M Unseld, GW Prager - International journal of molecular …, 2016 - mdpi.com
Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands
depending on their composition and regulate all processes which enable multicellular life. In …

[HTML][HTML] Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery

J Schnittert, R Bansal, G Storm, J Prakash - Advanced drug delivery reviews, 2018 - Elsevier
Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well.
Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which …