Alzheimer's disease (AD) is characterized by extracellular aggregates of amyloid β peptides,
intraneuronal tau aggregates, and neuronal death. This pathology triggers activation of …

Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD)
progression and are potential therapeutic targets. However, microglia exhibit diverse …

Proliferation and activation of microglia in the brain, concentrated around amyloid plaques,
is a prominent feature of Alzheimer's disease (AD). Human genetics data point to a key role …

Alzheimer's disease (AD) is the most prevalent form of dementia and is characterized by
abnormal extracellular aggregates of amyloid-β and intraneuronal hyperphosphorylated tau …

Microglia are resident immune cells in the central nervous system and play critical roles in
brain immunity, development, and homeostasis. The pathology of Alzheimer's disease (AD) …

Damage-associated microglia (DAM) profiles observed in Alzheimer's disease (AD)-related
mouse models reflect an activation state that could modulate AD risk or progression. To …

Research into the function of microglia has dramatically accelerated during the last few
years, largely due to recent genetic findings implicating microglia in virtually every …

Microglia-mediated neuroinflammation has been implicated in the pathogenesis of
Alzheimer's disease (AD). Although microglia in aging and neurodegenerative disease …

Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …

The extent of microglial heterogeneity in humans remains a central yet poorly explored
question in light of the development of therapies targeting this cell type. Here, we investigate …