Bioactive DNA from extracellular vesicles and particles

EZ Malkin, SV Bratman - Cell death & disease, 2020 - nature.com
Extracellular vesicles (EVs) and particles (EPs) have recently emerged as active carriers of
molecular biomarkers and mediators of intercellular communication. While most …

DNA in extracellular vesicles: biological and clinical aspects

J Elzanowska, C Semira, B Costa‐Silva - Molecular Oncology, 2021 - Wiley Online Library
The study of extracellular vesicles (EVs), especially in the liquid biopsy field, has rapidly
evolved in recent years. However, most EV studies have focused on RNA or protein content …

EV‐ADD, a database for EV‐associated DNA in human liquid biopsy samples

T Tsering, M Li, Y Chen, A Nadeau… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) play a key role in cellular communication both in physiological
conditions and in pathologies such as cancer. Emerging evidence has shown that EVs are …

DNA in extracellular vesicles: From evolution to its current application in health and disease

J Ghanam, VK Chetty, L Barthel, D Reinhardt… - Cell & Bioscience, 2022 - Springer
Extracellular vesicle (EV) secretion is a highly conserved evolutionary trait in all organisms
in the three domains of life. The packaging and release of EVs appears to be a bulk-flow …

Extracellular vesicles and their nucleic acids for biomarker discovery

F Momen-Heravi, SJ Getting, SA Moschos - Pharmacology & therapeutics, 2018 - Elsevier
Extracellular vesicles (EVs) are a heterogenous population of vesicles originate from cells.
EVs are found in different biofluids and carry different macromolecules, including proteins …

Functional transferred DNA within extracellular vesicles

J Cai, G Wu, PA Jose, C Zeng - Experimental cell research, 2016 - Elsevier
Extracellular vesicles (EVs) are small membrane vesicles including exosomes and shedding
vesicles that mediated a cell-to-cell communication. EVs are released from almost all cell …

Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges

RE Lane, D Korbie, MM Hill, M Trau - Clinical and translational medicine, 2018 - Springer
Extracellular vesicles (EVs) are small, lipid-bound particles containing nucleic acid and
protein cargo which are excreted from cells under a variety of normal and pathological …

Polyethylene glycol improves current methods for circulating extracellular vesicle-derived DNA isolation

N García-Romero, R Madurga, G Rackov… - Journal of translational …, 2019 - Springer
Abstract Background Extracellular vesicles (EVs) are small membrane-bound vesicles which
play an important role in cell-to-cell communication. Their molecular cargo analysis is …

Analysis of extracellular vesicle DNA at the single‐vesicle level by nano‐flow cytometry

H Liu, Y Tian, C Xue, Q Niu, C Chen… - Journal of extracellular …, 2022 - Wiley Online Library
It has been demonstrated recently that extracellular vesicles (EVs) carry DNA; however,
many fundamental features of DNA in EVs (EV‐DNA) remain elusive. In this study, a …

Strategies for the use of extracellular vesicles for the delivery of therapeutics

S Sil, RS Dagur, K Liao, ES Peeples, G Hu… - Journal of Neuroimmune …, 2020 - Springer
Extracellular vesicles (EVs) are nanosized, membrane-bound vesicles released from
eukaryotic and prokaryotic cells that can transport cargo containing DNA, RNA, lipids and …