Objective. To compare the respective effects of established measures used for management
of traumatic brain injury (TBI) patients on cerebral blood flow (CBF) and cerebral metabolic …

Background: Osmotic agents are widely used to lower elevated intracranial pressure (ICP).
However, little data are available regarding cerebral oxygenation and metabolism in the …

Therapies to lower intracranial pressure (ICP) after traumatic brain injury (TBI) include
hyperventilation (HV), intravenous mannitol (IM), and cerebrospinal fluid drainage from a …

Background: The impact of osmotic therapies on brain oxygen has not been extensively
studied in humans. We examined the effects on brain tissue oxygen tension (PbtO2) of …

Object. Hyperventilation therapy, blood pressure augmentation, and metabolic suppression
therapy are often used to reduce intracranial pressure (ICP) and improve cerebral perfusion …

Objective Hyperventilation is a controversial treatment in traumatic brain injury (TBI).
Prophylactic severe hyperventilation (below 3.3 kPa/25 mm Hg) is generally avoided, due to …

Traumatic brain injury (TBI) consists of varied pathophysiological consequences and
alteration of intracranial dynamics, reduction of the cerebral blood flow and oxygenation. In …

Severe head injury is frequently associated with focal or global disturbances of cerebral
blood flow and metabolism. Routine monitoring of intracranial pressure (ICP) and cerebral …

The potential superiority of hypertonic saline (HTS) over mannitol (MTL) for control of
intracranial pressure (ICP) following traumatic brain injury (TBI) is still debated. Forty-seven …

BACKGROUND: Mannitol has traditionally been the mainstay of medical therapy for
intracranial hypertension in patients with head injury. We previously demonstrated that …