Cholesterol is a critical component of membrane bilayers where it plays key structural and
functional roles by regulating the activity of diverse signaling platforms and pathways …

Correct lipid homeostasis at the plasma membrane is essential for cell survival and
performance. These are critically challenged in the aging brain. Changes in the levels of …

Cholesterol, an essential component of cell membranes, plays an important role in the
maintenance of cellular homeostasis and transmembrane communication within and …

Cholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized,
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …

Major advances in understanding cholesterol dynamics and the role that cholesterol plays in
vascular disease have recently been made. The brain is an organ that is highly enriched in …

Neurodegeneration, a common feature for many brain disorders, has severe consequences
on the mental and physical health of an individual. Typically human neurodegenerative …

Cholesterol is a ubiquitous and essential component of cellular membranes, as it regulates
membrane structure and fluidity. Furthermore, cholesterol serves as a precursor for steroid …

Neurodegeneration and its loss of cognitive function is associated with inflammation and an
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …

Cholesterol is essential for neuronal physiology, both during development and in the adult
life: as a major component of cell membranes and precursor of steroid hormones, it …

Cholesterol homeostasis is impaired in Alzheimer's disease; however, attempts to modulate
brain cholesterol biology have not translated into tangible clinical benefits for patients to …