Discovery and characterization of alamandine: a novel component of the renin–angiotensin system
RQ Lautner, DC Villela, RA Fraga-Silva… - Circulation …, 2013 - Am Heart Assoc
Rationale: The renin–angiotensin system (RAS) is a key regulator of the cardiovascular
system, electrolyte, and water balance. Here, we report identification and characterization of …
system, electrolyte, and water balance. Here, we report identification and characterization of …
New components of the renin-angiotensin system: alamandine and the MAS-related G protein-coupled receptor D
GM Etelvino, AAB Peluso, RAS Santos - Current hypertension reports, 2014 - Springer
The renin-angiotensin system is an important component of the central and humoral
mechanisms of blood pressure and hydro-electrolytic balance control. Angiotensin II is a key …
mechanisms of blood pressure and hydro-electrolytic balance control. Angiotensin II is a key …
Alamandine: a new member of the angiotensin family
DC Villela, DG Passos-Silva… - Current opinion in …, 2014 - journals.lww.com
Alamandine: a new member of the angiotensin family : Current Opinion in Nephrology and
Hypertension Alamandine: a new member of the angiotensin family : Current Opinion in …
Hypertension Alamandine: a new member of the angiotensin family : Current Opinion in …
[HTML][HTML] Alamandine and its receptor MrgD pair up to join the protective arm of the renin-angiotensin system
J Schleifenbaum - Frontiers in Medicine, 2019 - frontiersin.org
Only a few years ago, alamandine was found to be a member of the protective arm of the
renin-angiotensin system. It turned out to be an endogenous ligand of the G protein-coupled …
renin-angiotensin system. It turned out to be an endogenous ligand of the G protein-coupled …
Angiotensin (1-7) and alamandine: similarities and differences
T Qaradakhi, V Apostolopoulos, A Zulli - Pharmacological research, 2016 - Elsevier
A primary peptide of the renin angiotensin system (RAS), Angiotensin (Ang) II, is a
vasoconstrictor and promotor of atherosclerosis. To counter this, the RAS also consists of …
vasoconstrictor and promotor of atherosclerosis. To counter this, the RAS also consists of …
[HTML][HTML] Alamandine attenuates hypertension and cardiac hypertrophy in hypertensive rats
C Liu, CX Yang, XR Chen, BX Liu, Y Li, XZ Wang… - Amino Acids, 2018 - Springer
Oral administration of the peptide alamandine has antihypertensive and anti-fibrotic effects
in rats. This work aimed to determine whether subcutaneous alamandine injection would …
in rats. This work aimed to determine whether subcutaneous alamandine injection would …
[HTML][HTML] The renin-angiotensin system: going beyond the classical paradigms
RAS Santos, GY Oudit… - American Journal …, 2019 - journals.physiology.org
Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …
Angiotensins as therapeutic targets beyond heart disease
DG Passos-Silva, E Brandan, RAS Santos - Trends in Pharmacological …, 2015 - cell.com
The renin–angiotensin system (RAS) plays a pivotal role in cardiovascular and hydro-
electrolyte homeostasis. Blockade of the RAS as a therapeutic strategy for treating …
electrolyte homeostasis. Blockade of the RAS as a therapeutic strategy for treating …
ACE inhibition, ACE2 and angiotensin-(1 7) axis in kidney and cardiac inflammation and fibrosis
ACS e Silva, MM Teixeira - Pharmacological research, 2016 - Elsevier
Abstract The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …
[HTML][HTML] Angiotensin A/Alamandine/MrgD axis: another clue to understanding cardiovascular pathophysiology
The renin-angiotensin system (RAS) plays a crucial role in cardiovascular regulations and
its modulation is a challenging target for the vast majority of cardioprotective strategies …
its modulation is a challenging target for the vast majority of cardioprotective strategies …