Precise control of transcriptional programmes underlying metazoan development is
modulated by enzymatically active co-regulatory complexes, coupled with epigenetic …

Transcription factors and chromatin modifiers are important in the programming and
reprogramming of cellular states during development,. Transcription factors bind to …

Gene regulation in eukaryotes requires the coordinate interaction of chromatin-modulating
proteins with specific transcription factors such as the androgen receptor. Gene activation …

Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1
(LSD1) causes either gene repression or activation,. As a component of co-repressor …

Wnt genes comprise a large family of secreted polypeptides that are expressed in spatially
and tissue-restricted patterns during vertebrate embryonic development. Mutational analysis …

Histone methylation is crucial for regulating chromatin structure, gene transcription and the
epigenetic state of the cell. LSD1 is a lysine-specific histone demethylase that represses …

We identify LSD1 (lysine-specific demethylase 1; also known as KDM1A and AOF2) as a key
histone modifier that participates in the maintenance of pluripotency through the regulation …

Steroid hormones fulfil important functions in animal development. In Drosophila, ecdysone
triggers moulting and metamorphosis through its effects on gene expression. Ecdysone …

Gene transcription is critically influenced by chromatin structure and the modification status
of histone tails. Methylation of lysine residues in histone tails is dynamically regulated by the …

We have previously described a multiprotein complex termed the BHC or BRAF–HDAC
complex, which is required for the repression of neuronal-specific genes. We have shown …