Review on the recent advances on typhoid vaccine development and challenges ahead

KA Syed, T Saluja, H Cho, A Hsiao… - Clinical Infectious …, 2020 - academic.oup.com
Control of Salmonella enterica serovar typhi (S. typhi), the agent of typhoid fever, continues
to be a challenge in many low-and middle-income countries. The major transmission route …

Typhoid fever & vaccine development: a partially answered question

SA Marathe, A Lahiri, VD Negi… - Indian Journal of …, 2012 - journals.lww.com
Typhoid fever is a systemic disease caused by the human specific Gram-negative pathogen
Salmonella enterica serovar Typhi (S. Typhi). The extra-intestinal infections caused by …

Why is eradicating typhoid fever so challenging: implications for vaccine and therapeutic design

YA Yang, A Chong, J Song - Vaccines, 2018 - mdpi.com
Salmonella enterica serovar Typhi (S. Typhi) and S. Paratyphi, namely typhoidal
Salmonellae, are the cause of (para) typhoid fever, which is a devastating systemic …

[PDF][PDF] Typhoid vaccines: WHO position paper

World Health Organization - Weekly Epidemiological Record …, 2008 - apps.who.int
Data mainly from Asia, Africa and Latin America show that typhoid fever continues to be a
public health problem in many developing countries, with school-age children (aged 5–15 …

Vaccines for typhoid fever and other salmonelloses

LB Martin - Current opinion in infectious diseases, 2012 - journals.lww.com
Current typhoid vaccines, although moderately effective for short periods of time, cannot be
used in all age groups and only target one of the clinically relevant Salmonella serovars …

Efficacy of typhoid vaccines against culture-confirmed Salmonella Typhi in typhoid endemic countries: a systematic review and meta-analysis

R Batool, ZH Qamar, RA Salam… - The Lancet Global …, 2024 - thelancet.com
Background Typhoid is a serious public health threat in many low-income and middle-
income countries. Several vaccines for typhoid have been recommended by WHO for …

Vaccines against typhoid fever

CA Guzman, S Borsutzky, M Griot-Wenk, IC Metcalfe… - Vaccine, 2006 - Elsevier
Because of high infectivity and significant disease burden, typhoid fever constitutes a major
global health problem. Implementation of adequate food handling practices and …

The unrecognized burden of typhoid fever

SK Obaro, PY Iroh Tam, ED Mintz - Expert Review of Vaccines, 2017 - Taylor & Francis
ABSTRACT Introduction: Typhoid fever (TF), caused by Salmonella enterica serovar Typhi,
is the most common cause of enteric fever, responsible for an estimated 129,000 deaths and …

Using a human challenge model of infection to measure vaccine efficacy: a randomised, controlled trial comparing the typhoid vaccines M01ZH09 with placebo and …

TC Darton, C Jones, CJ Blohmke… - PLoS neglected …, 2016 - journals.plos.org
Background Typhoid persists as a major cause of global morbidity. While several licensed
vaccines to prevent typhoid are available, they are of only moderate efficacy and unsuitable …

Typhoid fever vaccination strategies

KA Date, A Bentsi-Enchill, F Marks, K Fox - Vaccine, 2015 - Elsevier
Typhoid vaccination is an important component of typhoid fever prevention and control, and
is recommended for public health programmatic use in both endemic and outbreak settings …