Background Effective chemotherapy rapidly reduces the spin–lattice relaxation of water
protons (T 1) in solid tumours and this change (ΔT 1) often precedes and strongly correlates …

Purpose: Identification of a generic response biomarker by comparison of
chemotherapeutics with different action mechanisms on several noninvasive biomarkers in …

Biomarkers predicting rapalog responses in sarcomas where PI3K and mTOR are often
hyperactivated could improve the suitable recruitment of responsive patients to clinical trials …

This study aims to explore whether the water exchange rate constants in tumor cells can act
as a hallmark of pathology status and a reporter of therapeutic outcomes. It has been shown …

Tumor responses to therapy in the clinic are still evaluated primarily from non-invasive
imaging measurements of reductions in tumor size. This approach, however, lacks sensitivity …

Noninvasive functional imaging of tumors can provide valuable early-response biomarkers,
in particular, for targeted chemotherapy. Using various experimental tumor models, we have …

Acidity, generated in hypoxia or hypermetabolic states, perturbs homeostasis and is a
feature of solid tumors. That acid peripherally disperses lysosomes is a three‐decade‐old …

This study aimed to test whether [18 F] fluoro-D-glucose (FDG) uptake of tumours measured
by positron emission tomography (PET) can be used as surrogate marker to define the …

Background Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with
chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The …

Cancer continues to be one of the major causes of death worldwide in the 21st century,
responsible for 6 million (12%) of the worldwide total deaths [1]. Throughout their lifetime …