The prevalence of various hepatic diseases increases dramatically worldwide and regarded
as a serious health problem. Sirtuins are one of the main strategic controllers of different …

Summary Sirtuin 1 (SIRT1) is involved in important biological processes such as energy
metabolism and regulatory functions of the cell cycle, apoptosis, and inflammation. Our …

Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …

Polyphenols synthesized by plants and fungi have various pharmacological effects. The
ability of polyphenols to modulate sirtuins has gained considerable interest due to the role of …

Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF) as a result of
accumulated drugs in the human body metabolized into toxic agents and helps generate …

Quercetin is the major representative of the flavonoid subgroup of flavones, with good
pharmacological activities for the treatment of liver diseases, including liver steatosis, fatty …

Obesity-induced insulin resistance is the principal cause of type 2 diabetes worldwide. The
use of natural products for the treatment of diabetes is increasingly attracting attention …

Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …

SIRT6 has been reported to have multiple functions in inflammation and metabolism. In the
present study, we explored the regulatory effects and mechanisms of SIRT6 in …

This article is directed at highlighting the involvement of the endogenous stress sensor
SIRT1 (silent information regulator T1) as a possible factor involved in hepatoprotection. The …