Understanding the extracellular vesicle surface for clinical molecular biology

S Hallal, Á Tűzesi, GE Grau… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐membrane enclosed nanoparticles that play significant
roles in health and disease. EVs are abundant in body fluids and carry an array of molecules …

Emerging methods in biomarker identification for extracellular vesicle‐based liquid biopsy

Y Liang, BM Lehrich, S Zheng… - Journal of Extracellular …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are released by many cell types and distributed within various
biofluids. EVs have a lipid membrane‐confined structure that allows for carrying unique …

Extracellular vesicles and their nucleic acids for biomarker discovery

F Momen-Heravi, SJ Getting, SA Moschos - Pharmacology & therapeutics, 2018 - Elsevier
Extracellular vesicles (EVs) are a heterogenous population of vesicles originate from cells.
EVs are found in different biofluids and carry different macromolecules, including proteins …

Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform

A Rai, H Fang, B Claridge, RJ Simpson… - Journal of …, 2021 - Wiley Online Library
The extracellular vesicle (EV) surface proteome (surfaceome) acts as a fundamental
signalling gateway by bridging intra‐and extracellular signalling networks, dictates EVs' …

Technical challenges of working with extracellular vesicles

MI Ramirez, MG Amorim, C Gadelha, I Milic, JA Welsh… - Nanoscale, 2018 - pubs.rsc.org
Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with
potential applications in diagnosis, prognosis and therapeutic guidance in most pathological …

Detailed analysis of protein topology of extracellular vesicles–evidence of unconventional membrane protein orientation

A Cvjetkovic, SC Jang, B Konečná, JL Höög… - Scientific reports, 2016 - nature.com
Extracellular vesicles (EVs) are important mediators of intercellular communication that
change the recipient cell by shuttling lipids, RNA, or protein cargo between cells. Here, we …

Technologies and standardization in research on extracellular vesicles

S Gandham, X Su, J Wood, AL Nocera, SC Alli… - Trends in …, 2020 - cell.com
Extracellular vesicles (EVs) are phospholipid bilayer membrane-enclosed structures
containing RNAs, proteins, lipids, metabolites, and other molecules, secreted by various …

A novel three step protocol to isolate extracellular vesicles from plasma or cell culture medium with both high yield and purity

X Zhang, EGF Borg, AM Liaci, HR Vos… - Journal of extracellular …, 2020 - Taylor & Francis
Extracellular vesicles (EV) are membrane encapsulated nanoparticles that can function in
intercellular communication, and their presence in biofluids can be indicative for (patho) …

Extracellular vesicles, the liquid biopsy of the future

A Eguchi, E Kostallari, AE Feldstein, VH Shah - Journal of hepatology, 2019 - Elsevier
Extracellular vesicles (EVs) are cell-derived nano-and micro-size entities containing a
specific cargo from the cell of origin. They are abundant in body fluids, emphasizing their …

Molecular interactions at the surface of extracellular vesicles

EI Buzás, EÁ Tóth, BW Sódar… - Seminars in …, 2018 - Springer
Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large
oncosomes have been shown to participate in a wide variety of biological processes and are …