Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods

S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

[HTML][HTML] Recent advances in biocatalysis for drug synthesis

A Kinner, P Nerke, R Siedentop, T Steinmetz… - Biomedicines, 2022 - mdpi.com
Biocatalysis is constantly providing novel options for the synthesis of active pharmaceutical
ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also …

On the development of new biocatalytic processes for practical pharmaceutical synthesis

GW Huisman, SJ Collier - Current opinion in chemical biology, 2013 - Elsevier
Biocatalysis has established itself as a scalable and green technology for the production of a
broad range of pharmaceutical APIs and intermediates. The number and scope of …

Streamlining design, engineering, and applications of enzymes for sustainable biocatalysis

RA Sheldon, D Brady - ACS Sustainable Chemistry & Engineering, 2021 - ACS Publications
In this Perspective we show how an expansion of the scope and impact of biocatalysis in
industrial organic synthesis is enabled by streamlining the underpinning biocatalyst and …

Biocatalysis in drug discovery and development

A Fryszkowska, PN Devine - Current Opinion in Chemical Biology, 2020 - Elsevier
Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is
beginning to transform chemical synthesis in the pharmaceutical industry. This review …

Recent advances in developing chemoenzymatic processes for active pharmaceutical ingredients

Junhua, L Zhao, N Ran - Organic process research & development, 2007 - ACS Publications
Biocatalysis is becoming a transformational technology for chemical synthesis as a result of
recent advances in large-scale DNA sequencing, structural biology, protein expression, high …

[HTML][HTML] Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering

JR Marshall, J Mangas-Sanchez, NJ Turner - Tetrahedron, 2021 - Elsevier
Despite the growing impact of enzyme catalysis in industrial chemistry, the full potential of
this technology is yet to be unlocked. Accessing new chemistries and expanding the scope …

Enabling broader adoption of biocatalysis in organic chemistry

EO Romero, AT Saucedo, JR Hernández-Meléndez… - JACS Au, 2023 - ACS Publications
Biocatalysis is becoming an increasingly impactful method in contemporary synthetic
chemistry for target molecule synthesis. The selectivity imparted by enzymes has been …

[HTML][HTML] Biocatalysis explained: from pharmaceutical to bulk chemical production

EMM Abdelraheem, H Busch, U Hanefeld… - Reaction Chemistry & …, 2019 - pubs.rsc.org
Biocatalysis is one of the most promising technologies for the sustainable synthesis of
molecules for pharmaceutical, biotechnological and industrial purposes. From the gram to …

Biocatalysis: A pharma perspective

JP Adams, MJB Brown… - Advanced Synthesis …, 2019 - Wiley Online Library
Biocatalysis over the past few years has matured into an essential tool for modern, cost
effective and sustainable pharmaceutical manufacturing. While some reaction classes are …