Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods
S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …
[HTML][HTML] Recent advances in biocatalysis for drug synthesis
A Kinner, P Nerke, R Siedentop, T Steinmetz… - Biomedicines, 2022 - mdpi.com
Biocatalysis is constantly providing novel options for the synthesis of active pharmaceutical
ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also …
ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also …
On the development of new biocatalytic processes for practical pharmaceutical synthesis
GW Huisman, SJ Collier - Current opinion in chemical biology, 2013 - Elsevier
Biocatalysis has established itself as a scalable and green technology for the production of a
broad range of pharmaceutical APIs and intermediates. The number and scope of …
broad range of pharmaceutical APIs and intermediates. The number and scope of …
Streamlining design, engineering, and applications of enzymes for sustainable biocatalysis
RA Sheldon, D Brady - ACS Sustainable Chemistry & Engineering, 2021 - ACS Publications
In this Perspective we show how an expansion of the scope and impact of biocatalysis in
industrial organic synthesis is enabled by streamlining the underpinning biocatalyst and …
industrial organic synthesis is enabled by streamlining the underpinning biocatalyst and …
Biocatalysis in drug discovery and development
A Fryszkowska, PN Devine - Current Opinion in Chemical Biology, 2020 - Elsevier
Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is
beginning to transform chemical synthesis in the pharmaceutical industry. This review …
beginning to transform chemical synthesis in the pharmaceutical industry. This review …
Recent advances in developing chemoenzymatic processes for active pharmaceutical ingredients
Junhua, L Zhao, N Ran - Organic process research & development, 2007 - ACS Publications
Biocatalysis is becoming a transformational technology for chemical synthesis as a result of
recent advances in large-scale DNA sequencing, structural biology, protein expression, high …
recent advances in large-scale DNA sequencing, structural biology, protein expression, high …
[HTML][HTML] Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering
Despite the growing impact of enzyme catalysis in industrial chemistry, the full potential of
this technology is yet to be unlocked. Accessing new chemistries and expanding the scope …
this technology is yet to be unlocked. Accessing new chemistries and expanding the scope …
Enabling broader adoption of biocatalysis in organic chemistry
EO Romero, AT Saucedo, JR Hernández-Meléndez… - JACS Au, 2023 - ACS Publications
Biocatalysis is becoming an increasingly impactful method in contemporary synthetic
chemistry for target molecule synthesis. The selectivity imparted by enzymes has been …
chemistry for target molecule synthesis. The selectivity imparted by enzymes has been …
[HTML][HTML] Biocatalysis explained: from pharmaceutical to bulk chemical production
EMM Abdelraheem, H Busch, U Hanefeld… - Reaction Chemistry & …, 2019 - pubs.rsc.org
Biocatalysis is one of the most promising technologies for the sustainable synthesis of
molecules for pharmaceutical, biotechnological and industrial purposes. From the gram to …
molecules for pharmaceutical, biotechnological and industrial purposes. From the gram to …
Biocatalysis: A pharma perspective
JP Adams, MJB Brown… - Advanced Synthesis …, 2019 - Wiley Online Library
Biocatalysis over the past few years has matured into an essential tool for modern, cost
effective and sustainable pharmaceutical manufacturing. While some reaction classes are …
effective and sustainable pharmaceutical manufacturing. While some reaction classes are …