Background We aimed to investigate whether the benefits of blood pressure-lowering drugs
are proportional to baseline cardiovascular risk, to establish whether absolute risk could be …

Background The effects of pharmacological blood pressure lowering at normal or high-
normal blood pressure ranges in people with or without pre-existing cardiovascular disease …

Background Clinical practice guidelines have traditionally recommended blood pressure
treatment based primarily on blood pressure thresholds. In contrast, using predicted …

Background The benefits of blood pressure lowering treatment for prevention of
cardiovascular disease are well established. However, the extent to which these effects …

Background Worldwide treatment recommendations for lowering blood pressure continue to
be guided predominantly by blood pressure thresholds, despite strong evidence that the …

Background The benefits of reducing blood pressure are well established, but there remains
uncertainty about whether the magnitude of the effect varies with the initial blood pressure …

Background The effects of pharmacological blood-pressure-lowering on cardiovascular
outcomes in individuals aged 70 years and older, particularly when blood pressure is not …

Background: Randomized controlled trials (RCTs) of blood pressure (BP) lowering lend
themselves to be meta-analyzed to help providing evidence-based recommendations for …

Background The benefits of reducing blood pressure on the risks of major cardiovascular
disease are well established, but uncertainty remains about the comparative effects of …

Background Controversy exists as to whether the threshold for blood pressure-lowering
treatment should differ between people with and without type 2 diabetes. We aimed to …