Background Previous studies have revealed that ventrolateral orbital cortex (VLO) may play
an important role in the regulation of emotional behavior. However, it is not known what …

Objectives Although many studies have indicated that orbitofrontal cortex plays an important
role in the learning and retrieval of memory and subsequent decision-making, the role of …

The orbitofrontal cortex (OFC) is involved in emotional processing, and orbitofrontal
abnormalities have often been observed in various affective disorders. Thus, chronic …

Major depression is a prevalent and long-lasting psychiatric illness with severe functional
impairment and high suicide rate. We have previously shown that the ventrolateral orbital …

There is collecting evidence suggesting that the process of chromatin remodeling such as
changes in histone acetylation contribute to the formation of stress-related memory …

Valproic acid (VPA), widely used as mood stablizer, has been shown therapeutic effects in
controlling both episodes of mania and depression. The neurobiological actions by which …

Inappropriate fear expression and failure of fear extinction are commonly seen in patients
with post-traumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD) …

Previous reports indicate that the right ventrolateral prefrontal cortex (VLPFC) is involved in
emotional regulation. However, most such studies were performed under unphysiological …

Emotional disorders, such as anxiety and depression, represent a major societal problem;
however, the underlying neurological mechanism remains unknown. The ventral lateral …

Pavlovian fear conditioning and extinction procedures have long been used to study the
regulation of learned fear. The amygdala is vital for the association of cues and fear …