The understanding of manganese (Mn) biology, in particular its cellular regulation and role
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …

Manganese (Mn) is an essential heavy metal that is naturally found in the environment. Daily
intake through dietary sources provides the necessary amount required for several key …

Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …

Manganese (Mn) is an essential trace element, serving as a cofactor for several key
enzymes, such as glutamine synthetase, arginase, pyruvate decarboxylase, and …

Manganese (Mn) is an essential trace metal that is pivotal for normal cell function and
metabolism. Its homeostasis is tightly regulated; however, the mechanisms of Mn …

Manganese (Mn) is an essential mineral. It is present in virtually all diets at low
concentrations. The principal route of intake for Mn is via food consumption, but in …

Manganese (Mn) is an essential ubiquitous trace element that is required for normal growth,
development and cellular homeostasis. Exposure to high Mn levels causes a clinical …

The review addresses issues pertinent to Mn accumulation and its mechanisms of transport,
its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in …

Abstract Purpose of Review Manganese (Mn) is critical for neurodevelopment but also has
been implicated in the pathophysiology of several neurological diseases. We discuss how …

Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic.
Disease states, such as manganism, are associated with overexposure or accumulation of …