The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over
the past 50 years, elucidation of the insulin signalling network has provided important …

Insulin resistance is a feature of a number of clinical disorders, including type 2
diabetes/glucose intolerance, obesity, dyslipidaemia and hypertension clustering in the so …

Currently, we observe an epidemic expansion of diabetes mellitus. In subjects with Type 2
diabetes the resistance of fat, muscle and liver to insulin is the central pathophysiological …

Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public
health hazards, especially in today's Western societies. A causal-effect relationship has …

Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin.
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …

Diabetes Mellitus (DM) is amongst the most notable causes of years of life lost worldwide
and its prevalence increases perpetually. The disease is characterized as multisystemic …

In the wake of the worldwide increase in type-2 diabetes, a major focus of research is
understanding the signaling pathways impacting this disease. Insulin signaling regulates …