Glutamatergic transmission is widely implicated in neuropsychiatric disorders, and the
discovery that ketamine elicits rapid-acting antidepressant effects by modulating α-amino-3 …

A new age of antidepressants arose in 2006 with the publication of data describing the rapid-
acting antidepressant effects of ketamine and scopolamine. These clinical findings led to the …

α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors mediate most of
the excitatory neurotransmission and play a key role in synaptic plasticity in the mammalian …

Highlights•Better AMPAR positive allosteric modulators are being developed.•New
methodologies and approaches enhance the analysis of their activity in vitro.•AMPA positive …

The neurotransmitter glutamate and its receptors have long been of interest to scientists
involved in pharmaceutical research since dysfunction of the glutamatergic signalling …

Depression and anxiety often co-occur, and conventional monoamine-facilitating
antidepressants show efficacy against symptoms in both disorders. Rodent studies indicate …

In this article, we first review current knowledge of the AMPA and NMDA glutamate
receptors, their physiological properties and functions and their regulation by signaling …

Depression affects a large percentage of the general population and can produce
devastating consequences to affected individuals, families and society. Although the …

Major antidepressant agents increase synaptic levels of monoamines. Although the
monoamine hypothesis of depression remains a cornerstone of our understanding of the …

Depression is a major psychiatric disorder affecting more than 120 million people worldwide
every year. Changes in monoaminergic transmitter release are suggested to take part in the …