CSF neurochemical profile and cognitive changes in Parkinson's disease with mild cognitive impairment

F Paolini Paoletti, L Gaetani, G Bellomo, E Chipi… - npj Parkinson's …, 2023 - nature.com
Pathophysiological substrate (s) and progression of Parkinson's disease (PD) with mild
cognitive impairment (PD-MCI) are still matter of debate. Baseline cerebrospinal fluid (CSF) …

Amyloid-β and α-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease

AL Stav, D Aarsland, KK Johansen, E Hessen… - Parkinsonism & related …, 2015 - Elsevier
Introduction Cognitive impairment in early Parkinson's disease (PD) is common and distinct
from early Alzheimer's disease. Predictors and mechanisms are only partially known, but α …

Cerebrospinal fluid biomarkers of cognitive decline in Parkinson's disease

I Johar, B Mollenhauer, D Aarsland - International review of neurobiology, 2017 - Elsevier
Among the nonmotor symptoms in Parkinson's disease (PD), cognitive impairment is one of
the most common and devastating. Over recent years, mild cognitive impairment (MCI) has …

Associations between cerebrospinal fluid biomarkers and cognition in early untreated Parkinson's disease

RE Skogseth, K Bronnick, JB Pereira… - Journal of …, 2015 - content.iospress.com
Background: Mild cognitive impairment and dementia are common, clinically important
features of Parkinson's disease (PD). The underlying disease pathology is heterogeneous …

Cognitive impairment in Parkinson's disease: A clinical and pathophysiological overview

PRP Brandão, RP Munhoz, TC Grippe… - Journal of the …, 2020 - Elsevier
Cognitive dysfunction in Parkinson's disease (PD) has received increasing attention, and,
together with other non-motor symptoms, exert a significant functional impact in the daily …

Cerebrospinal fluid biomarkers and cognitive performance in non-demented patients with Parkinson's disease

JB Leverenz, GS Watson, J Shofer, CP Zabetian… - Parkinsonism & related …, 2011 - Elsevier
We tested the hypothesis that levels of CSF biomarkers associated with dementia and
cognitive impairment are correlated with cognitive performance in non-demented …

[HTML][HTML] Cerebrospinal fluid amyloid β1-42, tau, and alpha-synuclein predict the heterogeneous progression of cognitive dysfunction in Parkinson's disease

JH Kang - Journal of movement disorders, 2016 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a neurodegenerative disease with heterogeneous pathological
and clinical features. Cognitive dysfunction, a frequent non-motor complication, is a risk …

Do CSF biomarkers predict progression to cognitive impairment in Parkinson's disease patients? A systematic review

K Leaver, KL Poston - Neuropsychology review, 2015 - Springer
Many patients with Parkinson's disease (PD) will develop cognitive impairment. Cross-
sectional studies have shown that certain protein levels are altered in the cerebrospinal fluid …

CSF biomarkers reflecting protein pathology and axonal degeneration are associated with memory, attentional, and executive functioning in early-stage parkinson′ s …

LP Oosterveld, TI Kuiper, NK Majbour… - International journal of …, 2020 - mdpi.com
In early-stage Parkinson′ s disease (PD), cognitive impairment is common, and a variety of
cognitive domains including memory, attention, and executive functioning may be affected …

Integrated clinical features with plasma and multi-modal neuroimaging biomarkers to diagnose mild cognitive impairment in early drug-naive Parkinson's disease

Y Wang, H Ning, J Ren, C Pan, M Yu… - ACS Chemical …, 2022 - ACS Publications
The pathogenesis of cognitive impairment in Parkinson's disease (PD) patients remains
unclear, and there is no ideal diagnostic tool available at present. We assessed integrated …