This research investigated if pitavastatin (Pita) might protect rats' kidneys against
thioacetamide (TAA). By altering the PTEN/AKT/mTOR pathway, pitavastatin may boost …

Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure-and
cholesterol-lowering effects. Background Statins are effective in prevention of end-organ …

Atorvastatin (AT) has been alternatively used for managing diabetic complications in clinic.
However, AT-related therapeutic potentiality remains relatively unexplored, especially in …

Background. Independent of their lipid-lowering effects, 3-hydroxy-3-methylglutaryl
coenzyme A (HMG-CoA) reductase inhibitors have renal protective effects on various …

New Findings What is the central question of this study? This study was designed to
determine the renoprotective effects of atorvastatin treatment in an experimental model of …

Clinically, statins have long been used for the prevention and treatment of chronic renal
diseases, however, the underlying mechanisms are not fully elucidated. The present study …

Statins are known to lessen the severity of renal ischemia-reperfusion injury. The present
study was undertaken to define the mechanism of renoprotective actions of statins using a …

Background and aims. Gentamicin (GM) is still considered to be an important antibiotic
against life-threatening, gram-negative bacterial infections despite its known nephrotoxic …

Potential benefits of statins in the treatment of chronic kidney disease beyond lipid-lowering
effects have been described. However, molecular mechanisms involved in renoprotective …

It was demonstrated that fenofibrate and telmisartan exerted renoprotective effects in
ischemia/reperfusion (I/R) injury. Because the combination of fenofibrate and telmisartan …