METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury
L Wang, J Wang, P Yu, J Feng, G Xu, X Zhao… - Nature …, 2022 - nature.com
RNA m6A modification is the most widely distributed RNA methylation and is closely related
to various pathophysiological processes. Although the benefit of regular exercise on the …
to various pathophysiological processes. Although the benefit of regular exercise on the …
The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy
Background: N 6-Methyladenosine (m6A) methylation is the most prevalent internal
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …
mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification
Among several known RNA modifications, N6‐methyladenosine (m6A) is the most studied
RNA epitranscriptomic modification and controls multiple cellular functions during …
RNA epitranscriptomic modification and controls multiple cellular functions during …
Changes in m6A RNA methylation contribute to heart failure progression by modulating translation
T Berulava, E Buchholz, V Elerdashvili… - European journal of …, 2020 - Wiley Online Library
Aims Deregulation of epigenetic processes and aberrant gene expression are important
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …
Loss of m6A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury
R Gong, X Wang, H Li, S Liu, Z Jiang, Y Zhao… - Pharmacological …, 2021 - Elsevier
Abstract Aims N6-Methyladenosine (m 6 A), one of the important epigenitic modifications, is
very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in …
very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in …
m6A-mRNA methylation regulates cardiac gene expression and cellular growth
V Kmietczyk, E Riechert, L Kalinski… - Life science …, 2019 - life-science-alliance.org
Conceptually similar to modifications of DNA, mRNAs undergo chemical modifications,
which can affect their activity, localization, and stability. The most prevalent internal …
which can affect their activity, localization, and stability. The most prevalent internal …
Mettl14 attenuates cardiac ischemia/reperfusion injury by regulating wnt1/β-catenin signaling pathway
P Pang, Z Qu, S Yu, X Pang, X Li, Y Gao… - Frontiers in Cell and …, 2021 - frontiersin.org
N6-methyladenosine (m6A) methylation in RNA is a dynamic and reversible modification
regulated by methyltransferases and demethylases, which has been reported to participate …
regulated by methyltransferases and demethylases, which has been reported to participate …
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes
H Song, X Feng, H Zhang, Y Luo, J Huang, M Lin… - Autophagy, 2019 - Taylor & Francis
ABSTRACT N6-methyladenosine (m6A) mRNA modifications play critical roles in various
biological processes. However, no study addresses the role of m6A in macroautophagy …
biological processes. However, no study addresses the role of m6A in macroautophagy …
Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts
T Li, Y Zhuang, W Yang, Y Xie, W Shang… - The FASEB …, 2021 - Wiley Online Library
Cardiac fibrosis is characterized by the activation of cardiac fibroblasts and accumulation of
extracellular matrix. METTL3, a component of methyltransferase complex, participates in …
extracellular matrix. METTL3, a component of methyltransferase complex, participates in …
Aging-associated differences in epitranscriptomic m6A regulation in response to acute cardiac ischemia/reperfusion injury in female mice
X Su, Y Shen, Y Jin, I Kim, NL Weintraub… - Frontiers in …, 2021 - frontiersin.org
Elderly patients are more susceptible to ischemic injury. N6-methyladenosine (m6A)
modification is the most abundant reversible epitranscriptomic modification in mammalian …
modification is the most abundant reversible epitranscriptomic modification in mammalian …