[HTML][HTML] Licochalcone D ameliorates oxidative stress-induced senescence via AMPK activation

N Maharajan, CD Ganesan, C Moon, CH Jang… - International Journal of …, 2021 - mdpi.com
Increased oxidative stress is a crucial factor for the progression of cellular senescence and
aging. The present study aimed to investigate the effects of licochalcone D (Lico D) on …

[HTML][HTML] Camphorquinone promotes the antisenescence effect via activating AMPK/SIRT1 in stem cells and D-galactose-induced aging mice

N Maharajan, GW Cho - Antioxidants, 2021 - mdpi.com
Terpenoids are a wide class of secondary metabolites with geroprotective properties that
can alter the mechanism of aging and aging-related diseases. Camphorquinone (CQ) is a …

[HTML][HTML] Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment

J Olloquequi, M Ettcheto, A Cano, A Fortuna… - International journal of …, 2023 - mdpi.com
Licochalcone A (Lico-A) is a flavonoid compound derived from the root of the Glycyrrhiza
species, a plant commonly used in traditional Chinese medicine. While the Glycyrrhiza …

Sargahydroquinoic acid (SHQA) suppresses cellular senescence through Akt/mTOR signaling pathway

L Cao, SG Lee, SH Park, HR Kim - Experimental gerontology, 2021 - Elsevier
Aim The effects of sargahydroquinoic acid (SHQA) on cellular senescence and the
underlying mechanisms were investigated using human umbilical vascular endothelial cells …

Genistein protects against ox-LDL-induced senescence through enhancing SIRT1/LKB1/AMPK-mediated autophagy flux in HUVECs

H Zhang, X Yang, X Pang, Z Zhao, H Yu… - Molecular and Cellular …, 2019 - Springer
The anti-senescence activity of genistein is associated with inducing autophagy; however,
the underlying mechanisms are not fully understood. In this study, human umbilical vein …

[HTML][HTML] Celastrol alleviates angiotensin II‑mediated vascular smooth muscle cell senescence via induction of autophagy

XJ Xu, WB Zhao, SB Feng, C Sun… - Molecular …, 2017 - spandidos-publications.com
Reactive oxygen species (ROS) production has been implicated in the promotion of cellular
senescence. Celastrol, a quinone methide triterpenoid isolated from the Celastraceae …

Lico A Enhances Nrf2‐Mediated Defense Mechanisms against t‐BHP‐Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells

H Lv, H Ren, L Wang, W Chen… - Oxidative Medicine and …, 2015 - Wiley Online Library
Licochalcone A (Lico A) exhibits various biological properties, including anti‐inflammatory
and antioxidant activities. In this study, we investigated the antioxidative potential and …

Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated …

J Li, Y Zhou, G Du, X Qin, L Gao - European Journal of Pharmacology, 2019 - Elsevier
Our previous work suggested that baicalein could delay senescence and improve cognitive
dysfunction in senescence-accelerated mouse prone 8 (SAMP8). Although baicalein has …

Quinovic Acid Impedes Cholesterol Dyshomeostasis, Oxidative Stress, and Neurodegeneration in an Amyloid‐β‐Induced Mouse Model

K Saeed, SA Shah, R Ullah, SI Alam… - Oxidative Medicine …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder typified by several
neuropathological features including amyloid‐beta (Aβ) plaque and neurofibrillary tangles …

[HTML][HTML] Licochalcone A suppresses the proliferation of osteosarcoma cells through autophagy and ATM-Chk2 activation

TS Shen, YK Hsu, YF Huang, HY Chen, CP Hsieh… - Molecules, 2019 - mdpi.com
Licochalcone A, a flavonoid extracted from licorice root, has been shown to exhibit broad
anti-inflammatory, anti-bacterial, anticancer, and antioxidative bioactivity. In this study, we …