Background Emerging evidence indicates that epigenetic modulation of gene expression
plays a key role in the progression of autosomal dominant polycystic kidney disease …

The pan-histone deacetylase (HDAC) inhibitor, trichostatin A, was found to reduce cyst
progression and slow the decline of kidney function in Pkd2 knockout mice, model of …

Epigenetics is the study of all heritable changes in gene expression and chromatin
organization that are caused by mechanisms independent of the DNA sequence itself …

The roles of epigenetic modulation of gene expression and protein functions in autosomal
dominant polycystic kidney disease (ADPKD) have recently become the focus of scientific …

Autosomal dominant polycystic kidney disease (ADPKD) is a common human genetic
disease characterized by the formation of multiple fluid-filled cysts in bilateral kidneys …

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that
results in end-stage kidney disease, due to the uncontrolled bilateral growth of cysts …

Autosomal dominant polycystic kidney disease (ADPKD) is a heritable disease
characterized by bilateral renal enlargement due to the growth of cysts throughout the …

Autosomal dominant polycystic kidney disease (ADPKD) is associated with progressive
enlargement of multiple renal cysts, often leading to renal failure that cannot be prevented …

Adult-onset autosomal-dominant polycystic kidney disease (ADPKD) is caused by mutations
in either the PKD1 or PKD2 gene, leading to malfunction of their gene products, polycystin 1 …

Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by
the formation of fluid-filled cysts in the kidney and end stage renal disease by the fourth or …