4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent lung carcinogen present in
tobacco products, and exposure to it is likely one of the factors contributing to the …

The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is an important
tobacco-specific carcinogen associated with lung cancer. Its complex enzymatic activation …

(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a nicotine-derived nitrosamine, is a
potent pulmonary carcinogen present in tobacco smoke. DNA adducts induced by …

Abstract The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is a powerful lung carcinogen in animal models and is considered a causative factor …

The tobacco specific pulmonary carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is metabolically activated to electrophilic species that form methyl and pyridyloxobutyl …

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
potent pulmonary carcinogen in laboratory animals. It is classified as a Group 1 human …

Tobacco smoke is a complex mixture of more than 7000 chemicals, of which many are toxic
and/or carcinogenic. Many hazard assessments of tobacco have focused on individual …

As a widespread industrial chemical, formaldehyde carcinogenicity has been highly
controversial. Meanwhile, formaldehyde is an essential metabolite in all living cells …

DNA can be damaged through covalent modifications of the nucleobases by endogenous
processes. These modifications, commonly referred to as DNA adducts, can persist and may …

Tobacco smoke is a complex mixture of chemicals, many of which are toxic and
carcinogenic. Hazard assessments of tobacco smoke exposure have predominantly focused …