Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: A phase 1b randomised, controlled, double-blinded, age de …

A Ouédraogo, EC Bougouma, NMQ Palacpac… - Frontiers in …, 2023 - frontiersin.org
Background BK-SE36/CpG is a recombinant blood-stage malaria vaccine candidate based
on the N-terminal Plasmodium falciparum serine repeat antigen5 (SE36), adsorbed to …

Phase 1b randomized trial and follow-up study in Uganda of the blood-stage malaria vaccine candidate BK-SE36

NMQ Palacpac, E Ntege, A Yeka, B Balikagala… - PLoS …, 2013 - journals.plos.org
Background Up to now a malaria vaccine remains elusive. The Plasmodium falciparum
serine repeat antigen-5 formulated with aluminum hydroxyl gel (BK-SE36) is a blood-stage …

First-in-human randomised trial and follow-up study of Plasmodium falciparum blood-stage malaria vaccine BK-SE36 with CpG-ODN (K3)

S Ezoe, NMQ Palacpac, K Tetsutani, K Yamamoto… - Vaccine, 2020 - Elsevier
Background BK-SE36 is blood-stage malaria vaccine candidate that is undergoing clinical
trials. Here, the safety and immunogenicity of BK-SE36 with a novel adjuvant, CpG-ODN …

Antibody titres and boosting after natural malaria infection in BK-SE36 vaccine responders during a follow-up study in Uganda

M Yagi, NMQ Palacpac, K Ito, Y Oishi, S Itagaki… - Scientific Reports, 2016 - nature.com
The malaria vaccine BK-SE36 is a recombinant protein (SE36) based on the Honduras 1
serine repeat antigen-5 of Plasmodium falciparum, adsorbed to aluminium hydroxide gel …

[HTML][HTML] Plasmodium falciparum infection coinciding with the malaria vaccine candidate BK-SE36 administration interferes with the immune responses in Burkinabe …

AB Tiono, NMQ Palacpac, EC Bougouma… - Frontiers in …, 2023 - frontiersin.org
Background A vaccine targeting the erythrocyte stages of Plasmodium falciparum could play
a role in preventing clinical disease. BK-SE36 is a promising malaria vaccine candidate that …

Safety and immunogenicity of BK-SE36 in a blinded, randomized, controlled, age de-escalating phase Ib clinical trial in Burkinabe children

EC Bougouma, NMQ Palacpac, AB Tiono… - Frontiers in …, 2022 - frontiersin.org
Background A blood-stage vaccine targeting the erythrocytic-stages of the malaria parasite
Plasmodium falciparum could play a role to protect against clinical disease. Antibodies …

Protective Epitopes of the Plasmodium falciparum SERA5 Malaria Vaccine Reside in Intrinsically Unstructured N-Terminal Repetitive Sequences

M Yagi, G Bang, T Tougan, NMQ Palacpac, N Arisue… - PLoS …, 2014 - journals.plos.org
The malaria vaccine candidate antigen, SE36, is based on the N-terminal 47 kDa domain of
Plasmodium falciparum serine repeat antigen 5 (SERA5). In epidemiological studies, we …

TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models

T Tougan, T Aoshi, C Coban, Y Katakai… - Human Vaccines & …, 2013 - Taylor & Francis
The SE36 antigen, derived from serine repeat antigen 5 (SERA5) of Plasmodium falciparum,
is a promising blood stage malaria vaccine candidate. Ongoing clinical trials suggest the …

A randomized first-in-human phase I trial of differentially adjuvanted Pfs48/45 malaria vaccines in Burkinabé adults

AB Tiono, JL Plieskatt, A Ouedraogo… - The Journal of …, 2024 - Am Soc Clin Investig
BACKGROUND Malaria transmission-blocking vaccines aim to interrupt the transmission of
malaria from one person to another. METHODS The candidates R0. 6C and ProC6C share …

Safety, Immunogenicity and Efficacy of Prime-Boost Vaccination with ChAd63 and MVA Encoding ME-TRAP against Plasmodium falciparum Infection in Adults in …

VA Mensah, A Gueye, M Ndiaye, NJ Edwards… - PLoS …, 2016 - journals.plos.org
Malaria transmission is in decline in some parts of Africa, partly due to the scaling up of
control measures. If the goal of elimination is to be achieved, additional control measures …