Cell–cell junctions are specializations of the plasma membrane responsible for physically
integrating cells into tissues. We are now beginning to appreciate the diverse impacts that …

Cell–cell contacts are major determinants of tissue organization in both health and disease.
Adhesive interactions, especially those mediated by classical cadherin receptors, influence …

Cells integrate biochemical and mechanical information to function within multicellular
tissue. Within developing and remodeling tissues, mechanical forces contain instructive …

Epithelial and endothelial monolayers are multicellular sheets that form barriers between the
'outside'and 'inside'of tissues. Cell-cell junctions, made by adherens junctions, tight junctions …

Cell-to-cell junctions are crucial mechanical and signaling hubs that connect cells within
tissues and probe the mechanics of the surrounding environment. Although the capacity of …

Cell adhesion systems are defined by their ability to resist detachment force. Our
understanding of the biology of cell–cell adhesions has recently been transformed by the …

Cadherin-based cell–cell adhesions are a primary determinant of tissue structure. For
several decades, it had been thought that the primary function of these ubiquitous structures …

All cells are subjected to mechanical forces throughout their lifetimes. These forces are
sensed by cell surface adhesion receptors and trigger robust actin cytoskeletal …

During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs)
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …

The shaping of a multicellular body, and the maintenance and repair of adult tissues require
fine-tuning of cell adhesion responses and the transmission of mechanical load between the …