Transcriptomic and metabolomic analyses provide insights into the attenuation of neuroinflammation by nervonic acid in MPTP-stimulated PD model mice

X Wang, X Zhu, X Li, Z Li, Y Mao, S Zhang, X Liu… - Food & Function, 2023 - pubs.rsc.org
Nervonic acid is one of the most promising bioactive fatty acids, which is believed to be
beneficial for the recovery of human cognitive disorders. However, the detailed …

Integrated metabolomics and transcriptomics reveal the neuroprotective effect of nervonic acid on LPS-induced AD model mice

X Wang, Z Li, X Li, X Liu, F Cao, X Zhu… - Biochemical …, 2023 - Elsevier
Nervonic acid (NA) is one of the long-chain fatty acids with significant biological activity that
has been widely studied in recent years. It is believed that NA may play a crucial role in the …

Nervonic acid improves liver inflammation in a mouse model of Parkinson's disease by inhibiting proinflammatory signaling pathways and regulating metabolic …

X Wang, T Liang, Y Mao, Z Li, X Li, X Zhu, F Cao… - Phytomedicine, 2023 - Elsevier
Background Nervonic acid (NA)—a type of bioactive fatty acid that is found in natural
sources—can inhibit inflammatory reactions and regulate immune system balance …

[HTML][HTML] Nervonic acid amends motor disorder in a mouse model of Parkinson's disease

D Hu, Y Cui, J Zhang - Translational Neuroscience, 2021 - degruyter.com
Objectives Parkinson's disease (PD) is a kind of common neurodegenerative disease in the
world. Previous studies have proved that nervonic acid (NA), extracted from Xanthoceras …

[HTML][HTML] Neuroprotective effect of a medium-chain triglyceride ketogenic diet on MPTP-induced Parkinson's disease mice: A combination of transcriptomics and …

W Zhang, S Chen, X Huang, H Tong, H Niu… - Cell Death Discovery, 2023 - nature.com
The ketogenic diet (KD) is a low carbohydrate and high-fat protein diet. It plays a protective
role in neurodegenerative diseases by elevating the levels of ketone bodies in blood …

Nervonic acid ameliorates motor disorder in mice with Parkinson's Disease

D Hu, Y Cui, J Zhang - Neurochemical Journal, 2021 - Springer
Objectives: Parkinson's disease (PD) is a kind of common neurodegenerative disease in the
world. Previous studies have proved that nervonic acid (NA), extracted from Xanthoceras …

Vancomycin pretreatment on MPTP-induced Parkinson's disease mice exerts neuroprotection by suppressing inflammation both in brain and gut

C Cui, H Hong, Y Shi, Y Zhou, CM Qiao… - Journal of Neuroimmune …, 2023 - Springer
A growing body of evidence implies that gut microbiota was involved in pathogenesis of
Parkinson's disease (PD), but the mechanism is still unclear. The aim of this study is to …

[HTML][HTML] Multi-Omics Integration in Mice With Parkinson's Disease and the Intervention Effect of Cyanidin-3-O-Glucoside

W Wang, G Zhu, Y Wang, W Li, S Yi, K Wang… - Frontiers in aging …, 2022 - frontiersin.org
Background Parkinson's disease (PD) is a multifactorial degenerative disease of the central
nervous system, which affects mostly older adults. To date, research has focused on the …

Anti-inflammatory effects of myristic acid mediated by the NF-κB pathway in lipopolysaccharide-induced BV-2 microglial cells

Q Huang, C Chen, Z Zhang, Q Xue - Molecular Omics, 2023 - pubs.rsc.org
Parkinson's disease (PD) is a serious neurodegenerative disorder wherein changes in
metabolites related to lipids, glutathione, and energy metabolism occur. Currently …

[HTML][HTML] Neuroprotective effects of sodium butyrate by restoring gut microbiota and inhibiting TLR4 signaling in mice with MPTP-induced Parkinson's disease

TT Guo, Z Zhang, Y Sun, RY Zhu, FX Wang, LJ Ma… - Nutrients, 2023 - mdpi.com
Parkinson's disease (PD) is a prevalent type of neurodegenerative disease. There is
mounting evidence that the gut microbiota is involved in the pathogenesis of PD. Sodium …