Multilamellar bodies (MLBs) are responsible for surfactant secretion in type II alveolar cells
but also accumulate in other cell types under pathological conditions, including cancer and …

Transfection of Mv1Lu mink lung type II alveolar cells with β1–6-N-acetylglucosaminyl
transferase V is associated with the expression of large lysosomal vacuoles, which are …

Recently a noncanonical activity of autophagy proteins has been discovered that targets
lipidation of microtubule-associated protein 1 light chain 3 (LC3) onto macroendocytic …

Chaperone‐mediated autophagy (CMA) is a selective mechanism for the degradation of
soluble cytosolic proteins in lysosomes. The limiting step of this type of autophagy is the …

Morphological and biochemical studies have shown that autophagosomes fuse with
endosomes forming the so‐called amphisomes, a prelysosomal hybrid organelle. In the …

Mucolipidosis type IV (MLIV) is a lysosomal storage disorder caused by mutations in the
MCOLN1 gene, a member of the transient receptor potential (TRP) cation channel gene …

Autophagy is a cellular stress response that results in the activation of a lysosomal
degradation pathway. In this report, we showed that cationic lipids, a common-used class of …

The process of macroautophagy (herein referred to as autophagy) involves the formation of
a closed double-membrane structure, called the autophagosome, and its subsequent fusion …

The lysosomal calcium channel TRPML1, whose mutations cause the lysosomal storage
disorder (LSD) mucolipidosis type IV (MLIV), contributes to upregulate autophagic genes by …

Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-
directed process of autophagy. An organelle-selective form of this process (macrolipophagy) …