Introduction Hevin, a matricellular protein involved in tissue repair and remodeling, is crucial
for initiation and development of excitatory synapses. Besides, α-amino-3-hydroxy-5-methyl …

The astrocytes-secreted active molecule, Hevin considerably contributes in the transsynaptic
bridge of neurexin1β/neuligin1 in excitatory synapse. Previous studies have demonstrated …

Background One of the major unresolved issues in treating pain is the paradoxical
hyperalgesia produced by opiates, and accumulating evidence implicate that Eph B s …

High endothelial venule protein/SPARC-like 1 (hevin/Sparcl1) is an astrocyte-secreted
protein that regulates synapse formation in the brain. Here we show that astrocytic hevin …

Background Accumulating studies have suggested that remifentanil, the widely-used opioid
analgesic in clinical anesthesia, can activate the pronociceptive systems and enhance …

BACKGROUND: Many studies have confirmed that brief remifentanil exposure can enhance
pain sensitivity. We previously reported that activation of glycogen synthase kinase-3β (GSK …

ABSTRACT Background and Objectives： Studying the underlying mechanisms of opiate-
induced hyperalgesia is fundamental to understanding and treating pain. Our previous study …

Background Remifentanil-induced hyperalgesia (RIH) may be a potential component for
acute confusional state and chronic pain after surgery, but specific mechanism remains …

BACKGROUND: Although remifentanil provides perfect analgesia during surgery,
postoperative hyperalgesia after remifentanil administration might be a challenge to …

Remifentanil is widely used to control intraoperative pain. However, its analgesic effect is
limited by the generation of postoperative hyperalgesia. In this study, we investigated …