Despite scientific advances, diabetic nephropathy remains both a therapeutical challenge,
and one of the major diabetic complications. Chemical structure of gangliosides, the most …

Ganglioside GM3 is particularly abundant in the kidney tissue and is thought to play an
important role in the maintenance of the charge-selective filtration barrier of glomeruli …

We recently identified ganglioside GM3 as a modulator of glomerular hypertrophy in
streptozotocin-induced diabetic rats (Life Sci., 72: 1997–2006, 2003). This study examined …

Ganglioside GM3 (NeuAcα3Galβ4Glcβ1Cer) is known to regulate the proliferation of many
cell types and to maintain the charge-selective filtration barrier of glomeruli. Based on these …

We demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance
focusing on the interaction between insulin receptor and GM3 ganglioside in adipocytes and …

The interactions between gangliosides and proteins belonging to the same or different lipid
domains and their influence on physiological and pathological states have been analysed in …

We recently found that albuminuria levels in patients with minimal change disease (MCD)
and focal segmental glomerulosclerosis (FSGS) inversely correlate with glycosphingolipid …

Background Gangliosides are amphipathic lipids ubiquitously expressed in all vertebrate
cells. They have been reported to play pivotal roles in cell morphology, cell adhesion, signal …

Gangliosides constitute a large family of sialic acid-containing glycosphingolipids which play
a key regulatory role in a diverse array of cellular processes, including receptor-associated …

Abrupt proliferation of glomerular mesangial cells (GMCs) is a common feature in the early
stage of diabetic glomerulopathy, and ganglioside GM3 (NeuAcα3Galβ4Glcβ1Cer) is …