Bioorthogonal microbubbles with antifouling nanofilm for instant and suspended enrichment of circulating tumor cells

Y Xiang, H Zhang, H Lu, B Wei, C Su, X Qin, M Fang… - ACS …, 2023 - ACS Publications
Integrating clinical rare cell enrichment, culture, and single-cell phenotypic profiling is
currently hampered by the lack of competent technologies, which typically suffer from weak …

Capture and release of cancer cells by combining on-chip purification and off-chip enzymatic treatment

X Yu, B Wang, N Zhang, C Yin, H Chen… - … Applied Materials & …, 2015 - ACS Publications
As “liquid biopsies”, circulating tumor cells (CTCs) have been thought to hold significant
insights for cancer diagnosis and treatment. Despite the advances of microfluidic techniques …

Well‐Defined Nanostructured Biointerfaces: Strengthened Cellular Interaction for Circulating Tumor Cells Isolation

L Yu, P Tang, C Nie, Y Hou… - Advanced Healthcare …, 2021 - Wiley Online Library
The topographic features at the cell–material biointerface are critical for cellular sensing of
the extracellular environment (ECM) and have gradually been recognized as key factors that …

Fluidic multivalent membrane nanointerface enables synergetic enrichment of circulating tumor cells with high efficiency and viability

L Wu, H Ding, X Qu, X Shi, J Yang… - Journal of the …, 2020 - ACS Publications
The ubiquitous biomembrane interface, with its dynamic lateral fluidity, allows membrane-
bound components to rearrange and localize for high-affinity multivalent ligand–receptor …

[HTML][HTML] Buoyancy-activated cell sorting using targeted biotinylated albumin microbubbles

YR Liou, YH Wang, CY Lee, PC Li - PLoS One, 2015 - journals.plos.org
Cell analysis often requires the isolation of certain cell types. Various isolation methods
have been applied to cell sorting, including florescence-activated cell sorting and magnetic …

[HTML][HTML] Antibody-engineered red blood cell interface for high-performance capture and release of circulating tumor cells

H Shen, R Su, J Peng, L Zhu, K Deng, Q Niu, Y Song… - Bioactive Materials, 2022 - Elsevier
Circulating tumor cells (CTCs), as important liquid biopsy target, can provide valuable
information for cancer progress monitoring and individualized treatment. However, current …

[HTML][HTML] Sensitive and specific biomimetic lipid coated microfluidics to isolate viable circulating tumor cells and microemboli for cancer detection

JY Chen, WS Tsai, HJ Shao, JC Wu, JM Lai, SH Lu… - PloS one, 2016 - journals.plos.org
Here we presented a simple and effective membrane mimetic microfluidic device with
antibody conjugated supported lipid bilayer (SLB)“smart coating” to capture viable …

An acoustic droplet-induced enzyme responsive platform for the capture and on-demand release of single circulating tumor cells

X Wei, K Chen, B Cai, L Rao, Z Wang… - … applied materials & …, 2019 - ACS Publications
The recovery of rare single circulating tumor cells (CTCs) from patients has great potential to
facilitate the study of cell heterogeneity and cancer metastasis, which may promote the …

Antibody-Functional Microsphere-Integrated Filter Chip with Inertial Microflow for Size–Immune-Capturing and Digital Detection of Circulating Tumor Cells

Y Su, Q Tian, D Pan, L Hui, Y Chen… - … applied materials & …, 2019 - ACS Publications
Circulating tumor cells (CTCs) in blood is the direct cause of tumor metastasis. The isolation
and detection of CTCs in the whole blood is very important and of clinical value in early …

Self-Sterilizing and regeneratable microchip for the precise capture and recovery of viable circulating tumor cells from patients with cancer

L Hui, Y Su, T Ye, Z Liu, Q Tian, C He… - … applied materials & …, 2018 - ACS Publications
Cancer cells metastasize and are transported in the bloodstream, easily reaching any site in
the body through the blood circulation. A method designed to assess the number of …