Isochromosomes are mirror-imaged chromosomes with simultaneous duplication and
deletion of genetic material which may contain two centromeres to create isodicentric …

The set domain containing 2 (SETD2) histone methyltransferase, located at 3p2, specifically
trimethylates lysine 36 of histone H3 (H3K36me3). H3K36me3 is an active mark involved in …

Cancer is thought to be largely caused by genetic mutations that alter nucleotide sequences
of DNA, yet epigenetic factors are increasingly recognized to also play causative roles in …

The non-redundant histone methyltransferase SETD2 (SET domain containing 2; KMT3A) is
responsible for tri-methylation of lysine 36 on histone H3 (H3K36me3). Presence of the …

Epigenetic dysregulation is an important contributor to carcinogenesis. This is not surprising,
as chromatin—genomic DNA organized around structural histone scaffolding—serves as the …

Chromatin structure is a major barrier to gene transcription that must be disrupted and re-set
during each round of transcription. Central to this process is the Set2/SETD2 …

SETD2 encodes a histone H3 lysine 36 (H3K36) methyltransferase affected by mutations
and deletions in a wide variety of cancers. Whether SETD2 loss alone can initiate …

Chromatin structure and function is influenced by histone posttranslational modifications.
SET8 (also known as PR-Set7 and SETD8) is a histone methyltransferase that …

The H3 lysine 36 histone methyltransferase SETD2 is mutated across a range of human
cancers. Although other enzymes can mediate mono-and dimethylation, SETD2 is the …

Posttranslational modifications (PTMs) of tubulin specify microtubules for specialized cellular
functions and comprise what is termed a" tubulin code." PTMs of histones comprise an …