The αvβ3-and α5β1-integrins play a key role in angiogenesis, the formation of new vessels
in tissues that lack them. By serving as receptors for a variety of extracellular matrix proteins …

The outstanding physio-pathological role played by integrin receptors in living subjects
motivates the enormous interest shown by scientists worldwide for this topic. More than …

Integrins are cell adhesion receptors predominantly important during normal and tumor
angiogenesis. A sequence present on several extracellular matrix proteins composed of Arg …

The αvβ3 integrin is expressed on proliferating endothelial cells such as those present in
growing tumors, as well as on tumor cells of various origin. Tumor-induced angiogenesis …

Recent studies demonstrated that peptide and antibody antagonists of integrin αvβ3 block
angiogenesis and tumor growth. In this article, the design, synthesis and biological …

Integrins are a large family of dimeric receptors composed by α and β subunits that, once
bound to extracellular matrix (ECM) proteins, regulate a variety of cellular processes such as …

Tumor blood vessels can be selectively targeted by RGD-peptides that bind to αvβ3 integrin
on angiogenic endothelial cells. By inhibiting the binding of these integrins to its natural …

We study herein the multivalency effect of a cluster of αVβ3-ligands held on a
cyclodecapeptide template. An array of RAFT (c [-RGDfK-]) n derivatives containing from one …

The aim of the present study was to identify specific αvβ3/αvβ5 integrin antagonists active on
tumor-induced angiogenesis. To this purpose, in vitro integrin-binding assays were used to …

Integrins are involved in many cellular processes, including some pathological ones
associated with various cancers, both solid tumours and metastases. Since integrins are …