Despite enormous progress in the treatment of many malignancies, the development of
cancer resistance is still an important reason for cancer chemotherapy failure. Increasing …

Background: Because cancer is a complex disease, it is unlikely that a single mono
functional 'targeted'drug will be effective for treating this most advanced disease. Combined …

Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years.
Although the mechanisms of action and signaling pathways affected by most treatments with …

Cancer can arise due to mutations in numerous pathways present in our body and thus has
many alternatives for getting aggravated. Due to this attribute, it gets difficult to treat cancer …

In spite of the development of a large number of novel anticancer drugs over the years,
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …

Cancer is a multifactorial disease including interactions of complex genetic and
environmental factors. Clinical efficacy of anticancer chemotherapies is hampered by …

Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …

Introduction Cancer continues to be a big threat and its treatment is a huge challenge
among the medical fraternity. Conventional anti-cancer agents are losing their efficiency …

Over the past two decades, elucidation of the genetic defects that underlie cancer has
resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be …

Despite some advances in targeted therapeutics of human cancers, curative cancer
treatment still remains a tremendous challenge due to the occurrence of drug resistance. A …