Alternative splicing generates specialized protein isoforms that allow the heart to adapt
during development and disease. The recent discovery that mutations in the splicing factor …

Alternative splicing is an important mechanism used by the cell to generate greater
transcriptomic and proteomic diversity from the genome. In the heart, alternative splicing is …

Molecular and cellular mechanisms of mutations of splicing factors in heart function are not
well understood. The splicing of precursor mRNA is dependent on an essential group of …

Alternative splicing is an essential post-transcriptional process to generate multiple
functional RNAs or proteins from a single transcript. Progress in RNA biology has led to a …

RNA splicing contributes to a broad spectrum of post-transcriptional gene regulation during
normal development, as well as pathological manifestation of heart diseases. However, the …

RBM20 is a vertebrate-specific RNA-binding protein with two zinc finger (ZnF) domains, one
RNA-recognition motif (RRM)-type RNA-binding domain and an arginine/serine (RS)-rich …

RNA splicing represents a post-transcriptional mechanism to generate multiple functional
RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example …

Driven by rapidly evolving technologies in next-generation sequencing, alternative splicing
has emerged as a crucial layer in gene expression, greatly expanding protein diversity and …

Cell-type-specific splicing generates numerous alternatively spliced transcripts playing
important roles for organ development and homeostasis, but only a few tissue-specific …

Despite advances in therapeutics for heart failure and arrhythmias, a substantial proportion
of patients with cardiomyopathy do not respond to interventions, indicating a need to identify …