Premenstrual dysphoric disorder is a female affective disorder that is defined by mood
symptoms. The condition is linked to unstable progesterone concentrations. Progestin …

Estradiol is the “prototypic” sex hormone of women. Yet, women have another sex hormone,
which is often disregarded: Progesterone. The goal of this article is to provide a …

Premenstrual dysphoric disorder (PMDD) is characterized by the predictable onset of mood
and physical symptoms secondary to gonadal steroid fluctuation during the luteal phase of …

Rationale In premenstrual dysphoric disorder (PMDD), a condition that afflicts 3–8% of
women in fertile ages, the cyclic recurrence of debilitating mood symptoms is restricted to the …

Introduction: Neurosteroids are molecules that regulate physiological functions of the CNS.
There is increasing evidence suggesting that impaired neurosteroid biosynthesis has been …

Context Allopregnanolone is a metabolite from progesterone and a positive modulator of the
GABA A receptor. This endogenous steroid may induce negative mood in sensitive women …

Certain women experience negative mood symptoms as a result of progesterone during the
luteal phase of the menstrual cycle, progestagens in hormonal contraceptives, or the …

Rationale Reproductive mood disorders, including premenstrual dysphoria (PMD) and
postpartum depression (PPD), are characterized by affective dysregulation that occurs …

Postpartum depression has deleterious effects on childbearing persons globally. Existing
treatments have been largely extrapolated from those for other forms of depression and …

Mood and anxiety disorders are vastly overrepresented in women, and one important
contributor to these differences is the fluctuation in sex steroids in women during the …