Chronic use of opioids can produce opioid-induced hyperalgesia (OIH), and when used to
treat migraine, these drugs can result in increased pain and headache chronicity. We …

Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors are widely
distributed at different levels of the pain-processing pathway. Its action at the peripheral …

The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

Migraine is a neurovascular disorder that can be debilitating for individuals and society.
Current research focuses on finding effective analgesics and management strategies for …

Introduction Pituitary adenylate cyclase-activating polypeptide (PACAP) is found in two
functional isoforms, namely PACAP38 and PACAP27. The migraine-inducing properties of …

Background Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multipotent
neuropeptide widely distributed in the trigeminovascular system (TVS) and higher brain …

Migraine ranks among the most prevalent disorders worldwide, leading to disability and
decreased quality of life in patients. Recently, neurogenic inflammation has been …

This is a Commentary on an article in BJP by Walker, Sundrum & Hay, Br J Pharmacol 2014;
171: 1521–1533. Walker et al.(2014) examined the action of pituitary adenylate cyclase …

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a broadly expressed
neuropeptide which has diverse effects in both the peripheral and central nervous systems …

Migraine is a complex disorder with a wide spectrum of clinical symptoms, and affects more
than 16% of the general population. Despite its high heritability, the genetic basis of …