Cutaneous skeletal hypophosphatemia syndrome (CSHS) is caused by somatic mosaic
NRAS variants and characterized by melanocytic/sebaceous naevi, eye, and brain …

Background We recently demonstrated multilineage somatic mosaicism in cutaneous
skeletal hypophosphatemia syndrome (CSHS), which features epidermal or melanocytic …

The association of hypophosphataemic rickets with verrucous epidermal naevus (EN) and
elevated fibroblast growth factor 23 levels is known as cutaneous–skeletal …

Recent molecular genetic studies have revealed that Schimmelpenning-Feuerstein-Mims
syndrome (SFMS), which presents as sebaceous nevi, is a mosaic RASopathy caused by …

Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a rare disorder caused by
somatic mosaicism for the gain of function RAS mutations. Affected patients have segmental …

Keratinocytic epidermal nevi (KEN) are characterized clinically by permanent hyperkeratosis
in the distribution of Blaschko's lines and histologically by hyperplasia of epidermal …

Cutaneous skeletal hypophosphatemia syndrome (CSHS), caused by somatic RAS
mutations, features excess fibroblast growth factor-23 (FGF23) and skeletal dysplasia …

Epidermal nevus syndromes encompass a highly heterogeneous group of systemic
disorders, characterized by epidermal nevi, and a spectrum of neuromuscular, ocular, and …

Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a mosaic RASopathy
characterized by the association of dysplastic skeletal lesions, congenital skin nevi of …

We report the case of a child who presented with a giant melanocytic nevus with numerous
satellite nevi at birth and developed hypophosphatemic rickets due to excessive secretion of …