Tyrosine Kinase Inhibitors - StatPearls - NCBI Bookshelf US flag An official website of the
United States government Here's how you know NIH NLM Logo Access keys NCBI Homepage …

Cancer chemotherapy has been one of the major medical advances in the last few decades.
However, the drugs used for this therapy have a narrow therapeutic index, and often the …

Over the last ten years, several new and therapeutically relevant cancer drugs targeting
tyrosine kinase signaling pathways have been developed. Tyrosine kinase inhibitors (TKIs) …

Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of certain forms of
cancers, raising hopes for many patients with otherwise unresponsive tumours. While these …

Tyrosine kinases, first described as oncogenes, have been shown to play a role in normal
cellular processes. Aberrations in tyrosine kinase activity lead to disease states. For fifteen …

This review covers the literature on significant studies of small molecule inhibitors of the
epidermal growth factor receptor (EGF R), platelet-derived growth factor receptor (PDGF R) …

Cancer is the second leading cause of death in the western world. Despite advances in
diagnosis and treatment, overall survival of patients remains poor. Scientific advances in …

Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of
the improvements in the life quality of patients, their effectiveness is compromised by several …

Numerous small molecule synthetic tyrosine kinase inhibitors are in clinical development for
the treatment of human cancers. These fall into three broad categories: inhibitors of the …

Over the last decades, billions have been spent and huge efforts have been taken in basic
and clinical cancer research [CA Cancer J Clin 63: 11-30]. About a decade ago, the arms …