The many barriers impeding performance of clinical trials in critically ill children1 have
resulted in a paucity of evidence guiding bedside practice. 2 Children admitted to a …

More than 100 000 infants and children are admitted to neonatal and paediatric intensive
care units in the UK annually. Infections and sepsis remain a leading cause of admission …

3. Halpern SD, Randolph AG, Angus DC: No child left behind: Enrolling children and adults
simultaneously in critical care randomized trials. Crit Care Med 2009; 37: 2638–2641 4 …

In their recent editorial [1], Kanthimathinathan and Peters summarize progress made in
paediatric intensive care research during 2018 and report on the number of active paediatric …

The investigators asserted that low rates of resistance were “consistent with previous lack of
evidence for the emergence of resistance” with antibiotic-impregnated central venous …

In an accompanying Comment, Julian Savulescu9 argues that the small chance (perhaps
one in 10 000) of benefit would outweigh the negatives of treatment in intensive care …

Objective: Randomized clinical trials of novel critical care interventions are currently tested
in children only after documenting their safety in adults. Although this practice may protect …

Abstract Background Intensive Care Medicine set us the task of outlining a global clinical
research agenda for paediatric intensive care (PIC). In line with the clinical focus of this …

Ruth Gilbert and colleagues (April 23, p 1732) 1 recommend widespread use of antibiotic-
impregnated central venous catheters to prevent bloodstream infections in paediatric …

In an ideal world, clinicians would only administer therapies whose benefits are known to
outweigh their risks. Unfortunately, for many therapies this is simply not feasible. Therapies …