[HTML][HTML] A single-cell landscape of pre-and post-menopausal high-grade serous ovarian cancer ascites

W Chen, H Liu, X Huang, L Qian, L Chen, Y Zhou, Y Liu… - IScience, 2023 - cell.com
High-grade serous ovarian cancer (HGSOC) is a hormone-related cancer with high mortality
and poor prognosis. Based on the transcriptome of 57,444 cells in ascites from 10 patients …

[HTML][HTML] Identification of estrogen response-associated STRA6+ granulosa cells within high-grade serous ovarian carcinoma by single-cell sequencing

X Liu, Z Chen, L Zhang - Heliyon, 2024 - cell.com
Background High-grade serous ovarian carcinoma (HGSOC) is a pathologic subtype of
ovarian cancer (OC) with a more lethal prognosis. Extensive heterogeneity results in …

[HTML][HTML] Fallopian tube single cell analysis reveals myeloid cell alterations in high-grade serous ovarian cancer

J Brand, M Haro, X Lin, BJ Rimel, SM McGregor… - Iscience, 2024 - cell.com
Most high-grade serous ovarian cancers (HGSCs) likely initiate from fallopian tube (FT)
epithelia. While epithelial subtypes have been characterized using single-cell RNA …

Integrated molecular profiling of patient‐derived ovarian cancer models identifies clinically relevant signatures and tumor vulnerabilities

M Lupia, V Melocchi, F Bizzaro… - … Journal of Cancer, 2022 - Wiley Online Library
High‐grade serous ovarian carcinoma (HGSOC) is a highly aggressive and intractable
neoplasm, mainly because of its rapid dissemination into the abdominal cavity, a process …

[HTML][HTML] Comparative analysis between high-grade serous ovarian cancer and healthy ovarian tissues using single-cell RNA sequencing

X Zhang, S Hong, C Yu, X Shen, F Sun… - Frontiers in Oncology, 2023 - frontiersin.org
Introduction High-grade serous ovarian cancer (HGSOC) is the most common histological
subtype of ovarian cancer, and is associated with high mortality rates. Methods In this study …

[HTML][HTML] Th2 cells infiltrating high-grade serous ovarian cancer: a feature that may account for the poor prognosis

H Su, Y Jin, C Tao, H Yang, E Yang… - Journal of …, 2023 - ncbi.nlm.nih.gov
Objective We aimed to investigate the differences of transcriptome profile between 2 groups
of high-grade serous ovarian cancer (HGSOC) patients with distinct outcomes and identify …

Distinct transcriptional programs in ascitic and solid cancer cells induce different responses to chemotherapy in high-grade serous ovarian cancer

N Loret, N Vandamme, J De Coninck, J Taminau… - Molecular Cancer …, 2022 - AACR
High-grade serous ovarian cancer (HGSOC) is responsible for the largest number of ovarian
cancer deaths. The frequent therapy-resistant relapses necessitate a better understanding of …

[HTML][HTML] Immune profiling reveals prognostic genes in high-grade serous ovarian cancer

Y Wu, L Xia, P Zhao, Y Deng, Q Guo, J Zhu… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
High-grade serous ovarian cancer (HGSOC) is a heterogeneous disease with diverse
clinical outcomes, highlighting a need for prognostic biomarker identification. Here, we …

Single‐cell transcriptomes reveal heterogeneity of high‐grade serous ovarian carcinoma

Q Hao, J Li, Q Zhang, F Xu, B Xie, H Lu… - Clinical and …, 2021 - Wiley Online Library
Background High‐grade serous ovarian carcinoma (HGSOC) is the most common and
aggressive histotype of epithelial ovarian cancer. The heterogeneity and molecular basis of …

Molecular profiling and clinical outcome of high‐grade serous ovarian cancer presenting with low‐versus high‐volume ascites

T Feigenberg, B Clarke, C Virtanen… - BioMed research …, 2014 - Wiley Online Library
Epithelial ovarian cancer consists of multiple histotypes differing in etiology and clinical
course. The most prevalent histotype is high‐grade serous ovarian cancer (HGSOC), which …